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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox6tm2.1Vlf
targeted mutation 2.1, Veronique Lefevbre
MGI:3641204
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Sox6tm2.1Vlf/Sox6tm2.1Vlf
Tg(Prrx1-cre)1Cjt/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL MGI:3800360
cn2
 		Sox5tm2Vlf/Sox5tm2Vlf
Sox6tm2.1Vlf/Sox6tm2.1Vlf
Tg(Prrx1-cre)1Cjt/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL MGI:3800358
cn3
 		Sox5tm1Vlf/Sox5tm1Vlf
Sox6tm1Vlf/Sox6tm2.1Vlf
Tg(Col2a1-cre)1Bhr/0 		involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * SJL MGI:3641207


Genotype
MGI:3800360
cn1
Allelic
Composition		 Sox6tm2.1Vlf/Sox6tm2.1Vlf
Tg(Prrx1-cre)1Cjt/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox6tm2.1Vlf mutation (0 available); any Sox6 mutation (60 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:137217 )
• normal appearance at birth
• viable and fertile




Genotype
MGI:3800358
cn2
Allelic
Composition		 Sox5tm2Vlf/Sox5tm2Vlf
Sox6tm2.1Vlf/Sox6tm2.1Vlf
Tg(Prrx1-cre)1Cjt/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox5tm2Vlf mutation (0 available); any Sox5 mutation (45 available)
Sox6tm2.1Vlf mutation (0 available); any Sox6 mutation (60 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:137217 )
• small size

limbs/digits/tail
abnormal autopod morphology ( J:137217 )
• paws lack mineralized bone
abnormal radius morphology ( J:137217 )
• lacks cartillage
abnormal ulna morphology ( J:137217 )
• lacks cartillage
abnormal fibula morphology ( J:137217 )
• lacks cartillage
abnormal tibia morphology ( J:137217 )
• lacks cartillage

skeleton
abnormal radius morphology ( J:137217 )
• lacks cartillage
abnormal ulna morphology ( J:137217 )
• lacks cartillage
abnormal fibula morphology ( J:137217 )
• lacks cartillage
abnormal tibia morphology ( J:137217 )
• lacks cartillage
short sternum ( J:137217 )
• at birth




Genotype
MGI:3641207
cn3
Allelic
Composition		 Sox5tm1Vlf/Sox5tm1Vlf
Sox6tm1Vlf/Sox6tm2.1Vlf
Tg(Col2a1-cre)1Bhr/0
Genetic
Background		 involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox5tm1Vlf mutation (0 available); any Sox5 mutation (45 available)
Sox6tm1Vlf mutation (0 available); any Sox6 mutation (60 available)
Sox6tm2.1Vlf mutation (0 available); any Sox6 mutation (60 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal cartilage development ( J:110147 )
• poorly developed cartilage similar to double homozygous mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory