Phenotypes associated with this allele

• Allele Symbol: Hif1a^tm1Kats
• Allele Name: targeted mutation 1, Dorthe M Katschinski
• Allele ID: MGI:3641209
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hif1a^tm1Kats/Hif1a^tm1Kats	involves: 129 * C57BL/6	MGI:3698300

Genotype
MGI:3698300

hm1

• Allelic Composition: Hif1a^tm1Kats/Hif1a^tm1Kats
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cytokine level ( J:117857 )

• exhibit a significant up-regulation in production of proinflammatory cytokines upon TCR activation

increased interferon-gamma secretion ( J:117857 )

• lymph nodes produce more IFN-gamma upon TCR activation in both normoxic and hypoxic conditions

abnormal interleukin secretion ( J:117857 )

• lymph nodes produce more IL-2, IL-4, and IL-13 upon TCR activation, in both normoxic and hypoxic conditions

increased tumor necrosis factor secretion ( J:117857 )

• lymph nodes produce more TNF-alpha upon TCR activation in both normoxic and hypoxic conditions

homeostasis/metabolism

abnormal cytokine level ( J:117857 )

• exhibit a significant up-regulation in production of proinflammatory cytokines upon TCR activation