All Phenotypes Plxna1<tm1Kik> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Plxna1^tm1Kik
targeted mutation 1, Hitoshi Kikutani
MGI:3641211

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plxna1^tm1Kik/Plxna1^tm1Kik	either: B6.Cg-Plxna1^tm1Kik or C.Cg-Plxna1^tm1Kik	MGI:3641216
hm2	Plxna1^tm1Kik/Plxna1^tm1Kik	Not Specified	MGI:4462167
cx3	Plxna1^tm1Kik/Plxna1^tm1Kik Tg(TcraTcrb)425Cbn/?	involves: BALB/c * C57BL/6	MGI:4462168

Allelic Composition	Plxna1^tm1Kik/Plxna1^tm1Kik
Genetic Background	either: B6.Cg-Plxna1^tm1Kik or C.Cg-Plxna1^tm1Kik

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna1^tm1Kik mutation (0 available); any Plxna1 mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal CD4-positive, alpha-beta T cell physiology ( J:110786 )

• proliferation and cytokine production by CD4+ T cells is reduced compared to wild-type

abnormal dendritic cell physiology ( J:110786 )

• in vitro, dendritic cells poorly stimulate allogeneic T cell compared with wild-type; ability of dendritic cells to stimulate antigen-specific T cells is impaired

skeleton

abnormal long bone morphology ( J:110786 )

• cellularity is reduced in the long bones in null mice

increased trabecular bone mass ( J:110786 )

• long bones have increased trabecular mass compared to wild-type

hematopoietic system

abnormal CD4-positive, alpha-beta T cell physiology ( J:110786 )

• proliferation and cytokine production by CD4+ T cells is reduced compared to wild-type

Allelic Composition	Plxna1^tm1Kik/Plxna1^tm1Kik
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna1^tm1Kik mutation (0 available); any Plxna1 mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal dendritic cell physiology ( J:161856 )

• reduced migratory ability

• unable to migrate across lymphatic vessel endothelial cell layer

Allelic Composition	Plxna1^tm1Kik/Plxna1^tm1Kik Tg(TcraTcrb)425Cbn/?
Genetic Background	involves: BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna1^tm1Kik mutation (0 available); any Plxna1 mutation (75 available)
Tg(TcraTcrb)425Cbn mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:161856 )

• ova induced proliferative response is much reduced

hematopoietic system

decreased T cell proliferation ( J:161856 )

• ova induced proliferative response is much reduced

cellular

decreased T cell proliferation ( J:161856 )

• ova induced proliferative response is much reduced

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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