Phenotypes associated with this allele

• Allele Symbol: Tlr6^int
• Allele Name: insouciant
• Allele ID: MGI:3641228
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tlr6^int/Tlr6^int	C57BL/6-Tlr6^int	MGI:3641229

Genotype
MGI:3641229

hm1

• Allelic Composition: Tlr6^int/Tlr6^int
• Genetic Background: C57BL/6-Tlr6^int

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal adaptive immunity ( J:110094 )

abnormal cell-mediated immunity ( J:110094 )

abnormal innate immunity ( J:110094 )

abnormal macrophage physiology ( J:110094 )

• peritoneal macrophages from homozygous mice fail to secrete type 1 interferon in response to peptidoglycan, lipoteichoic acid or MALP-2, all of which induce signaling via the TLR2/TLR6 heterodimeer

• peritoneal macrophages from homozygous mice exhibit a partial type 1 interferon secretory response to PAM2CSK4 in a TLR2-dependent manner

• immunoblot analysis of lysates of homozygous mutant peritoneal macrophages using antibodies to phosphorylated proteins demonstrates failure of these cells to phosphorylate/activate IkappaB, JUN N-terminal kinase (JNK) or extracellular signal-related kinase (ERK) in response to MALP-2, a diacyl peptide that induces signaling TLR2 or the TLR2/TLR6 heterodimer

hematopoietic system

abnormal macrophage physiology ( J:110094 )

• peritoneal macrophages from homozygous mice fail to secrete type 1 interferon in response to peptidoglycan, lipoteichoic acid or MALP-2, all of which induce signaling via the TLR2/TLR6 heterodimeer

• peritoneal macrophages from homozygous mice exhibit a partial type 1 interferon secretory response to PAM2CSK4 in a TLR2-dependent manner

• immunoblot analysis of lysates of homozygous mutant peritoneal macrophages using antibodies to phosphorylated proteins demonstrates failure of these cells to phosphorylate/activate IkappaB, JUN N-terminal kinase (JNK) or extracellular signal-related kinase (ERK) in response to MALP-2, a diacyl peptide that induces signaling TLR2 or the TLR2/TLR6 heterodimer