Phenotypes associated with this allele

• Allele Symbol: Robo1^tm1.1Ljr
• Allele Name: targeted mutation 1.1, Linda J Richards
• Allele ID: MGI:3641236
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Robo1^tm1.1Ljr/Robo1^tm1.1Ljr	B6.129-Robo1^tm1.1Ljr	MGI:3653416

Genotype
MGI:3653416

hm1

• Allelic Composition: Robo1^tm1.1Ljr/Robo1^tm1.1Ljr
• Genetic Background: B6.129-Robo1^tm1.1Ljr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:109478 )

• complete mortality of homozygous mice at birth

nervous system

abnormal axon extension ( J:109478 )

• both corticothalamic and thalamocortical axons aberrantly arrived at their respective targets at least 1 day earlier than controls

abnormal axon guidance ( J:109478 )

• axon pathfinding defects included dysgenesis of the corpus callosum and hippocampal commissure, and abnormalities in corticothalamic and thalamocortical targeting

enhanced neuronal migration ( J:109478 )

• significantly more interneurons (up to twice as many at E12.5 and E15.5) migrated into the cortex in both rostral and parietal regions, but not caudal cortex

abnormal brain commissure morphology ( J:109478 )

abnormal corpus callosum morphology ( J:109478 )

• mis-projection of axons resulting in callosal axons and axons of the hippocampal commissure forming tight fascicles

decreased corpus callosum size ( J:109478 )

• reduction in the size of the corpus callosum was observed in the mid-sagittal plane

abnormal hippocampal commissure morphology ( J:109478 )

• disruption of hippocampal commissure tracts was evident in E17 and E18 embryo brains

• mis-projection of axons resulting in callosal axons and axons of the hippocampal commissure forming tight fascicles

decreased hippocampal commissure size ( J:109478 )

• reduction in the size of the hippocampal commissure was observed in the mid-sagittal plane

cellular

abnormal axon extension ( J:109478 )

• both corticothalamic and thalamocortical axons aberrantly arrived at their respective targets at least 1 day earlier than controls

abnormal axon guidance ( J:109478 )

• axon pathfinding defects included dysgenesis of the corpus callosum and hippocampal commissure, and abnormalities in corticothalamic and thalamocortical targeting

enhanced neuronal migration ( J:109478 )

• significantly more interneurons (up to twice as many at E12.5 and E15.5) migrated into the cortex in both rostral and parietal regions, but not caudal cortex