Phenotypes associated with this allele

• Allele Symbol: Pparg^tm2Mae
• Allele Name: targeted mutation 2, Nobuyo Maeda
• Allele ID: MGI:3641248
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Pparg^tm1Rev/Pparg^tm2Mae	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J	MGI:4412011
cx2	Atp2b2^m1Mae/Atp2b2^m1Mae Pparg^tm2Mae/Pparg^tm2Mae	involves: 129S6/SvEvTac * C57BL/6J	MGI:3641262
cx3	Atp2b2^m1Mae/Atp2b2^+ Pparg^tm2Mae/Pparg^+	involves: 129S6/SvEvTac * C57BL/6J	MGI:3641270

Genotype
MGI:4412011

ht1

• Allelic Composition: Pparg^tm1Rev/Pparg^tm2Mae
• Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased systemic arterial blood pressure ( J:154767 )

• in males and females at 4 months of age

• overall, decreased Pparg expression correlates with increased blood pressure

Genotype
MGI:3641262

cx2

• Allelic Composition: Atp2b2^m1Mae/Atp2b2^m1Mae; Pparg^tm2Mae/Pparg^tm2Mae
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

behavior/neurological

abnormal reflex ( J:110607 )

abnormal blinking ( J:110607 )

• absent eye blink reflex

absent pinna reflex ( J:110607 )

impaired righting response ( J:110607 )

• when attempting to right themselves mice frequently fall on their side and turn onto their back with alternating flexion and hypertonic musculature of the extremities

• righting takes more than 4 sec compared to 0-1 sec in wild-type mice

absent startle reflex ( J:110607 )

• no response to acoustic stimuli

abnormal vibrissae reflex ( J:110607 )

• absent

tremors ( J:110607 )

• severe tremors seen by P12

abnormal motor coordination/balance ( J:110607 )

ataxia ( J:110607 )

• evident by P12

impaired balance ( J:110607 )

• difficulty maintaining position when the cage is shaken and unable to stand on a stationary or rotating rod

decreased grip strength ( J:110607 )

• unable to grip an inverted wire

head bobbing ( J:110607 )

abnormal gait ( J:110607 )

• wobbly gait

hearing/vestibular/ear

impaired hearing ( J:110607 )

• profound hearing loss

growth/size/body

decreased body size ( J:110607 )

• adults are about half the size of control littermates

postnatal growth retardation ( J:110607 )

• begin to lag behind littermates around P10

nervous system

abnormal prepulse inhibition ( J:110607 )

• absent

Genotype
MGI:3641270

cx3

• Allelic Composition: Atp2b2^m1Mae/Atp2b2⁺; Pparg^tm2Mae/Pparg⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

hearing/vestibular/ear

impaired hearing ( J:110607 )

• severe hearing loss

behavior/neurological

decreased startle reflex ( J:110607 )

• decreased acoustic startle amplitude but normal movement and motor function

nervous system

abnormal prepulse inhibition ( J:110607 )

• absent