Phenotypes associated with this allele

• Allele Symbol: Fxn^tm1Pand
• Allele Name: targeted mutation 1, Massimo Pandolfo
• Allele ID: MGI:3641251
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Fxn^tm1Mkn/Fxn^tm1Pand	involves: 129/Sv * C57BL/6	MGI:3652375

Genotype
MGI:3652375

ht1

• Allelic Composition: Fxn^tm1Mkn/Fxn^tm1Pand
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:109164 )

• 2/13 mice died during the course of the experiment; 1 of these died at about 12 months of age

homeostasis/metabolism

increased heart iron level ( J:109164 )

• the mouse that died at about 12 months of age had 3-fold higher iron levels in the heart than littermates (1168 ug vs 399 ug)

cardiovascular system

increased heart iron level ( J:109164 )

• the mouse that died at about 12 months of age had 3-fold higher iron levels in the heart than littermates (1168 ug vs 399 ug)

cardiac fibrosis ( J:109164 )

• the mouse that died at ~ 12 months showed prominent heart fibrosis

immune system

brain inflammation ( J:216422 )

• inflammatory arachidonic metabolites are elevated in cerebellum

nervous system

brain inflammation ( J:216422 )

• inflammatory arachidonic metabolites are elevated in cerebellum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Friedreich ataxia		DOID:12705		J:216422