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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igh-Jtm1Khyk
targeted mutation 1, Kyoko Hayakawa
MGI:3641272
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Igh-Jtm1Khyk/Igh-J+ CB17.129X1-Igh-Jtm1Khyk MGI:3713663


Genotype
MGI:3713663
ht1
Allelic
Composition		 Igh-Jtm1Khyk/Igh-J+
Genetic
Background		 CB17.129X1-Igh-Jtm1Khyk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Khyk mutation (0 available); any Igh-J mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:109979 )
N
• B-1 B cells appear first in the white pulp of the spleen and expand in association with follicular dendritic cells in neonatal mice in both control and mutant animals
increased B-1 B cell number ( J:109979 )
• a dramatic increase in anti-phosphatidylcholine expressing the VH11mu heavy chain is seen in the white pulp of the spleen
• elevated numbers of CD5+ VH11/VH9 B cells with anti-phospatidylcholine specificity develop in mutant mice

immune system
increased B-1 B cell number ( J:109979 )
• a dramatic increase in anti-phosphatidylcholine expressing the VH11mu heavy chain is seen in the white pulp of the spleen
• elevated numbers of CD5+ VH11/VH9 B cells with anti-phospatidylcholine specificity develop in mutant mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory