Phenotypes associated with this allele

• Allele Symbol: Alo2
• Allele Name: alopecia 2
• Allele ID: MGI:3641310
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Alo2/Alo2	involves: C3H/HeJ * C57BL/6J	MGI:3652491
ht2	Alo2/Alo2^+	involves: C3H/HeJ * C57BL/6J	MGI:3652493

Genotype
MGI:3652491

hm1

• Allelic Composition: Alo2/Alo2
• Genetic Background: involves: C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

absent sebaceous gland ( J:109802 )

• by 2 weeks of age, sebaceous glands are only rarely found

alopecia ( J:109802 )

• at 3 weeks of age, mice begin to exhibit a subtle hair loss which progresses to a consistent, moderate hair loss at 4 weeks of age which diminishes slightly in severity at 7 weeks of age

• from 7 weeks to 12 weeks of age, mice display progressive hair loss until there is severe hair loss by 12 weeks

• by 20 weeks, mice show nearly complete alopecia except for sparse fur on the rostrum and perineal areas

abnormal hypodermis morphology ( J:109802 )

• at 3 weeks there is a perifollicular mostly mononuclear inflammatory infiltrate extending to the base of the hypodermal fat layer; at 5 weeks the infiltrate is concentrated around and within the follicles with destruction of follicles by necrosis being evident

abnormal hair follicle morphology ( J:109802 )

• by 3 weeks of age, most mutant follicles have an atrophic bulb and remain extended deep into the hypodemal fat layer

abnormal dermal layer morphology ( J:109802 )

• at 7 days of age, mutants show ~2-fold increased dermal cellularity compared to littermates

mixed cellular infiltration to dermis ( J:109802 )

• mutant dermis contains a diffuse, primarily mononuclear inflammatory cell infiltrate with occasional polymorphonuclear cells

thick epidermis ( J:109802 )

• at 7 days of age mutants display a 2-fold thickened epidermis compared to littermates

flaky skin ( J:109802 )

• mice display flaky skin at 3 weeks of age

reddish skin ( J:109802 )

• at 3 weeks affected mice have reddish skin

skin lesions ( J:109802 )

• the G1 males at 50 weeks of age showed moderate to severe excoriation and erosion of the scapular and suprascapular dermis

thick skin ( J:109802 )

• at 3 weeks of age, mutants display variable skin thickening

immune system

enlarged spleen ( J:109802 )

• many mice have enlarged spleens

abnormal lymph node morphology ( J:109802 )

• lymph nodes generally have an activated appearance with prominent secondary follicles and large number of macrophages containing yellow-brown pigment

enlarged lymph nodes ( J:109802 )

• superficial lymph nodes are enlarged at 3 weeks; mice 5 weeks old or more have multiple enlarged lymph nodes

lymph node necrosis ( J:109802 )

• the inguinal, axillary and occasionally mesenteric lymph nodes are dark grey with regions that appear necrotic

hematopoietic system

enlarged spleen ( J:109802 )

• many mice have enlarged spleens

extramedullary hematopoiesis ( J:109802 )

• spleens have a mild to moderate amount of extramedullary hematopoiesis with frequent granulocyte precursors present

increased bone marrow cell number ( J:109802 )

• bone marrow in most mice is highly cellular compared to controls

endocrine/exocrine glands

absent sebaceous gland ( J:109802 )

• by 2 weeks of age, sebaceous glands are only rarely found

growth/size/body

enlarged spleen ( J:109802 )

• many mice have enlarged spleens

Genotype
MGI:3652493

ht2

• Allelic Composition: Alo2/Alo2⁺
• Genetic Background: involves: C3H/HeJ * C57BL/6J

integument

absent sebaceous gland ( J:109802 )

• by 2 weeks of age, sebaceous glands are only rarely found

alopecia ( J:109802 )

• at 3 weeks of age, mice begin to exhibit a subtle hair loss which progresses to a consistent, moderate hair loss at 4 weeks of age which diminishes slightly in severity at 7 weeks of age

• from 7 weeks to 12 weeks of age, mice display progressive hair loss until there is severe hair loss by 12 weeks

• by 20 weeks, mice show nearly complete alopecia except for sparse fur on the rostrum and perineal areas

abnormal hypodermis morphology ( J:109802 )

• at 3 weeks there is a perifollicular mostly mononuclear inflammatory infiltrate extending to the base of the hypodermal fat layer; at 5 weeks the infiltrate is concentrated around and within the follicles with destruction of follicles by necrosis being evident

abnormal hair follicle morphology ( J:109802 )

• by 3 weeks of age, most mutant follicles have an atrophic bulb and remain extended deep into the hypodemal fat layer

abnormal dermal layer morphology ( J:109802 )

• at 7 days of age, mutants show ~2-fold increased dermal cellularity compared to littermates

mixed cellular infiltration to dermis ( J:109802 )

• mutant dermis contains a diffuse, primarily mononuclear inflammatory cell infiltrate with occasional polymorphonuclear cells

thick epidermis ( J:109802 )

• at 7 days of age mutants display a 2-fold thickened epidermis compared to littermates

flaky skin ( J:109802 )

• mice display flaky skin at 3 weeks of age

reddish skin ( J:109802 )

• at 3 weeks affected mice have reddish skin

skin lesions ( J:109802 )

• the G1 males at 50 weeks of age showed moderate to severe excoriation and erosion of the scapular and suprascapular dermis

thick skin ( J:109802 )

• at 3 weeks of age, mutants display variable skin thickening

immune system

enlarged spleen ( J:109802 )

• many mice have enlarged spleens

abnormal lymph node morphology ( J:109802 )

• lymph nodes generally have an activated appearance with prominent secondary follicles and large number of macrophages containing yellow-brown pigment

enlarged lymph nodes ( J:109802 )

• superficial lymph nodes are enlarged at 3 weeks; mice 5 weeks old or more have multiple enlarged lymph nodes

lymph node necrosis ( J:109802 )

• the inguinal, axillary and occasionally mesenteric lymph nodes are dark grey with regions that appear necrotic

hematopoietic system

enlarged spleen ( J:109802 )

• many mice have enlarged spleens

extramedullary hematopoiesis ( J:109802 )

• spleens have a mild to moderate amount of extramedullary hematopoiesis with frequent granulocyte precursors present

increased bone marrow cell number ( J:109802 )

• bone marrow in most mice is highly cellular compared to controls

endocrine/exocrine glands

absent sebaceous gland ( J:109802 )

• by 2 weeks of age, sebaceous glands are only rarely found

growth/size/body

enlarged spleen ( J:109802 )

• many mice have enlarged spleens