endocrine/exocrine glands
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• high frequency of infiltrates of all sizes form in young mice
(J:77238)
• pancreatic islets show infiltrates where B cells line the islets and T cells are localized more distantly
(J:77238)
• invasive infiltrates are rare compared to Ccl19 and Ccl21b transgenic mice; large numbers of B cells accumulate next to clusters of islet cells but do not mix with islet cells
(J:77238)
• ~50% of islets are infiltrated to various degrees with small nucleated cells; most cells are naive B220+ B cells; pancreata contain high numbers of lymphocytes, with an enrichment in B lyphocytes compared to peripheral blood
(J:110548)
• B cells are localized adjacent to pancreatic beta cells while CD3+ T cells are localized more distantly
(J:110548)
• CD4 and CD8 T cells (showing low levels of acute activation) are also present in higher numbers than nontransgenic controls
(J:110548)
• islet architecture is frequently disturbed, resembling severe insulitis, but beta cell loss or diabetes is not seen
(J:110548)
• small infiltrates (>30 cells/section) are composed mainly of B cells, while medium-sized infiltrates (30-300 cells) have an increased number of B cells, T cells and DCs (dendritic cells) and HEVs and large-sized infiltrates (>~300 cells) have well defined T and B cell-rich zones
(J:110548)
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immune system
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• development of high endothelial venules (HEVs) is seen in infiltrates
• dense stromal network extends through most of the infiltrate
• HEV and stromal cell networks are present only in islets with lymphocytic infiltrate
• treatment of transgenics with lymphotoxin beta receptor (LTBR) protein causes large-sized infiltrates to disappear and a reduction in size and number of medium-sized infiltrates is observed with overall result appearing similar to Lta-deficient transgenic mice
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Analysis Tools