Phenotypes associated with this allele

• Allele Symbol: Slc2a8^tm1.1Thor
• Allele Name: targeted mutation 1.1, Bernard Thorens
• Allele ID: MGI:3641337
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc2a8^tm1.1Thor/Slc2a8^tm1.1Thor	involves: 129X1/SvJ * C57BL/6	MGI:3652573

Genotype
MGI:3652573

hm1

• Allelic Composition: Slc2a8^tm1.1Thor/Slc2a8^tm1.1Thor
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:109701 )

• homozygosity causes partial embryonic lethality since heterozygous matings produce only 17.4% homozygous pups instead of 25%

• however, when surviving homozygotes are crossed together or with heterozygotes, a normal litter size and genotype distribution is observed

nervous system

abnormal dentate gyrus morphology ( J:109701 )

• a 50% increase in proliferating cells is observed in the dentate gyrus

• however, no defects in memory acquisition or retention are observed

cardiovascular system

cardiovascular system phenotype ( J:109701 )

N • no changes in heart structure or histology are observed

prolonged P wave ( J:109701 )

• a 12% increase in P-wave duration is noted at 30 weeks of age despite normal P-wave morphology

• however, no differences in the PR, QT, or ST interval length or in the QRS complex duration are observed