Phenotypes associated with this allele

• Allele Symbol: Bmp2^tm1Vrs
• Allele Name: targeted mutation 1, Vicki Rosen
• Allele ID: MGI:3641368
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bmp2^tm1Vrs/Bmp2^tm1Vrs Nkx2-5^tm2(cre)Rph/Nkx2-5^+	involves: 129S1/Sv * C57BL/6	MGI:3641420

Genotype
MGI:3641420

cn1

• Allelic Composition: Bmp2^tm1Vrs/Bmp2^tm1Vrs; Nkx2-5^tm2(cre)Rph/Nkx2-5⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:110615 )

• conditional Bmp2 deletion results in death by E11.5; embryos are alive at E10.5

embryo

decreased embryo size ( J:110615 )

• conditional Bmp2-null embryos are smaller than wild-type controls at E10.5

growth/size/body

decreased embryo size ( J:110615 )

• conditional Bmp2-null embryos are smaller than wild-type controls at E10.5

cardiovascular system

abnormal heart development ( J:110615 )

• at E10.5, embryos have an abnormally patterned heart with an uncharacteristic, straight morphology to the region between the atria and ventricles

absent atrioventricular cushions ( J:110615 )

• endocardial cushions and EC mesenchyme are missing at E10.5, as well as the AV constriction

pericardial effusion ( J:110615 )

• some embryos show pericardial effusion

homeostasis/metabolism

pericardial effusion ( J:110615 )

• some embryos show pericardial effusion

cardiac edema ( J:110615 )

• some embryos show cardiac edema