All Phenotypes Chd4<tm1.1Kge> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Chd4^tm1.1Kge/Chd4^tm1.2Kge Tg(CAG-Bgeo/GFP)21Lbe/0 Tg(Lck-cre)1Cwi/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3713384
cn2	Chd3^tm1.1Cya/Chd3^tm1.1Cya Chd4^tm1.1Kge/Chd4^tm1.1Kge Tg(Tek-cre)1Ywa/0	involves: C57BL/6 * C57BL/6J * SJL	MGI:6456933
cn3	Chd4^tm1.1Kge/Chd4^tm1.2Kge Tg(Lck-cre)1Cwi/0	involves: C57BL/6 * SJL	MGI:3713382
cn4	Chd4^tm1.1Kge/Chd4^tm1.1Kge Tg(Lck-cre)1Cwi/0	involves: C57BL/6 * SJL	MGI:3713383

Allelic Composition	Chd4^tm1.1Kge/Chd4^tm1.2Kge Tg(CAG-Bgeo/GFP)21Lbe/0 Tg(Lck-cre)1Cwi/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd4^tm1.1Kge mutation (0 available); any Chd4 mutation (58 available)
Chd4^tm1.2Kge mutation (0 available); any Chd4 mutation (58 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation (2 available)
Tg(Lck-cre)1Cwi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell cycle ( J:109547 )

• progressive decrease in cycling T cells is observed from second to third cell division in vitro, along with large number of nonblast T cells that appear to fail to enter cell cycle

decreased T cell proliferation ( J:109547 )

• a 5- to 7-fold decrease in proliferation is observed relative to wild-type cells in vitro after 48 hours of TCR/CD3 stimulation; fewer mutant cells are in S phase

immune system

decreased T cell proliferation ( J:109547 )

• a 5- to 7-fold decrease in proliferation is observed relative to wild-type cells in vitro after 48 hours of TCR/CD3 stimulation; fewer mutant cells are in S phase

hematopoietic system

decreased T cell proliferation ( J:109547 )

• a 5- to 7-fold decrease in proliferation is observed relative to wild-type cells in vitro after 48 hours of TCR/CD3 stimulation; fewer mutant cells are in S phase

Allelic Composition	Chd3^tm1.1Cya/Chd3^tm1.1Cya Chd4^tm1.1Kge/Chd4^tm1.1Kge Tg(Tek-cre)1Ywa/0
Genetic Background	involves: C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd3^tm1.1Cya mutation (0 available); any Chd3 mutation (102 available)
Chd4^tm1.1Kge mutation (0 available); any Chd4 mutation (58 available)
Tg(Tek-cre)1Ywa mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:294633 )

• vascular rupture in E11.5 embryos

• normal vasculature in E10.5 embryos

hemorrhage ( J:294633 )

• in E11.5 embryos

mortality/aging

embryonic lethality, complete penetrance ( J:294633 )

• most embryos die between age E10.5-11.5

Allelic Composition	Chd4^tm1.1Kge/Chd4^tm1.2Kge Tg(Lck-cre)1Cwi/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thymus hypoplasia ( J:109547 )

• reduced in mutant mice

immune system

thymus hypoplasia ( J:109547 )

• reduced in mutant mice

endocrine/exocrine glands

thymus hypoplasia ( J:109547 )

• reduced in mutant mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased double-positive T cell number ( J:109547 )

• percentage of DP cells is reduced by 3-fold

arrested T cell differentiation ( J:109547 )

• differentiation of thymocytes stalls at the DN4 stage, but some do make the transition to DP eventually

• absolute number of double negative (DN) thymocytes is unaltered, or elevated despite decrease in thymus cellularity

increased CD8-positive, alpha-beta T cell number ( J:109547 )

• CD8 + T cells are increased to compensate for reduced DP cell numbers

abnormal CD4-positive, alpha beta T cell morphology ( J:109547 )

spleen hypoplasia ( J:109547 )

• 2- to 5-fold reduction in T cells in spleen is observed; decreased numbers of CD8+ and CD4+ populations is noted

abnormal T cell physiology ( J:109547 )

• DP and CD4+ T cells express lower levels of CD4, and CD8+ cells range from CD4^lo to CD4-

lymph node hypoplasia ( J:109547 )

• 2- to 5-fold reduction in T cells in lymph nodes is observed; decreased numbers of CD8+ and CD4+ populations is noted

hematopoietic system

decreased double-positive T cell number ( J:109547 )

• percentage of DP cells is reduced by 3-fold

arrested T cell differentiation ( J:109547 )

• differentiation of thymocytes stalls at the DN4 stage, but some do make the transition to DP eventually

• absolute number of double negative (DN) thymocytes is unaltered, or elevated despite decrease in thymus cellularity

increased CD8-positive, alpha-beta T cell number ( J:109547 )

• CD8 + T cells are increased to compensate for reduced DP cell numbers

abnormal CD4-positive, alpha beta T cell morphology ( J:109547 )

spleen hypoplasia ( J:109547 )

• 2- to 5-fold reduction in T cells in spleen is observed; decreased numbers of CD8+ and CD4+ populations is noted

abnormal T cell physiology ( J:109547 )

• DP and CD4+ T cells express lower levels of CD4, and CD8+ cells range from CD4^lo to CD4-

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24