Phenotypes associated with this allele

• Allele Symbol: Ly86^tm1Kmiy
• Allele Name: targeted mutation 1, Kensuke Miyake
• Allele ID: MGI:3641422
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ly86^tm1Kmiy/Ly86^tm1Kmiy	involves: 129P2/OlaHsd * C57BL/6	MGI:3653203

Genotype
MGI:3653203

hm1

• Allelic Composition: Ly86^tm1Kmiy/Ly86^tm1Kmiy
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell proliferation ( J:109720 )

• B cells show low proliferative responses to anti-RP105, lipid A or LPS from E. coli or S. minnesota

decreased IgG2b level ( J:137066 )

• reduced in serum at 7 and 11 weeks of age

decreased IgG3 level ( J:137066 )

• significantly reduced in serum at 7 and 11 weeks of age

increased IgG level ( J:109720 )

• B cells show low proliferative responses to anti-RP105, lipid A or LPS from E. coli or S. minnesota

increased IgM level ( J:109720 )

• mice show higher levels of IgM production than wild-type in response to TNP-LPS

hematopoietic system

decreased B cell proliferation ( J:109720 )

• B cells show low proliferative responses to anti-RP105, lipid A or LPS from E. coli or S. minnesota

decreased IgG2b level ( J:137066 )

• reduced in serum at 7 and 11 weeks of age

decreased IgG3 level ( J:137066 )

• significantly reduced in serum at 7 and 11 weeks of age

increased IgG level ( J:109720 )

• B cells show low proliferative responses to anti-RP105, lipid A or LPS from E. coli or S. minnesota

increased IgM level ( J:109720 )

• mice show higher levels of IgM production than wild-type in response to TNP-LPS

cellular

decreased B cell proliferation ( J:109720 )

• B cells show low proliferative responses to anti-RP105, lipid A or LPS from E. coli or S. minnesota