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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CD2-Sh2d1b1)#Vei
transgene insertion, Andre Veillette
MGI:3641447
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(CD2-Sh2d1b1)#Vei/0 B6.Cg-Tg(CD2-Sh2d1b1)#Vei MGI:3641452


Genotype
MGI:3641452
tg1
Allelic
Composition		 Tg(CD2-Sh2d1b1)#Vei/0
Genetic
Background		 B6.Cg-Tg(CD2-Sh2d1b1)#Vei
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired natural killer cell mediated cytotoxicity ( J:110195 )
• transgenic expression of Sh2d1b1 suppresses the ability of Il2-activated NK cells to kill target cells in vitro
decreased interferon-gamma secretion ( J:110195 )
• Il2-activated NK cells inhibit the production of Ifng in response to stimulation in vitro

hematopoietic system
impaired natural killer cell mediated cytotoxicity ( J:110195 )
• transgenic expression of Sh2d1b1 suppresses the ability of Il2-activated NK cells to kill target cells in vitro




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory