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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Xrcc4tm2.1Fwa
targeted mutation 2.1, Frederick W Alt
MGI:3641470
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Trp53tm1Brd/Trp53+
Xrcc4tm2.1Fwa/Xrcc4tm2Fwa
Tg(Nes-cre)1Kln/0 		involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * SJL MGI:3652715
cn2
 		Trp53tm1Brd/Trp53tm1Brd
Xrcc4tm2.1Fwa/Xrcc4tm2Fwa
Tg(Nes-cre)1Kln/0 		involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * SJL MGI:3652717


Genotype
MGI:3652715
cn1
Allelic
Composition		 Trp53tm1Brd/Trp53+
Xrcc4tm2.1Fwa/Xrcc4tm2Fwa
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (240 available)
Xrcc4tm2.1Fwa mutation (0 available); any Xrcc4 mutation (26 available)
Xrcc4tm2Fwa mutation (0 available); any Xrcc4 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:109585 )
N
• mice survive beyond 16 months




Genotype
MGI:3652717
cn2
Allelic
Composition		 Trp53tm1Brd/Trp53tm1Brd
Xrcc4tm2.1Fwa/Xrcc4tm2Fwa
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (240 available)
Xrcc4tm2.1Fwa mutation (0 available); any Xrcc4 mutation (26 available)
Xrcc4tm2Fwa mutation (0 available); any Xrcc4 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:109585 )
• mice become moribund between 12 and 14 weeks of age with 20/23 mice dead by 25 weeks

nervous system
increased medulloblastoma incidence ( J:109585 )
• mice develop medulloblastomas
abnormal cerebellar granule layer morphology ( J:109585 )
• mice at 4 and 8.5 weeks of age show multifocal tumor masses expanding from the granular layer
abnormal cerebellum vermis morphology ( J:109585 )
• at 12-14 weeks mice have aggressive medulloblastomas in the vermis or hemisphere

craniofacial
enlarged cranium ( J:109585 )
• at 12-14 weeks skulls of mice show rapid morphological enlargement

skeleton
enlarged cranium ( J:109585 )
• at 12-14 weeks skulls of mice show rapid morphological enlargement

neoplasm
increased medulloblastoma incidence ( J:109585 )
• mice develop medulloblastomas

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
 J:109585




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory