About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rcan2tm1Jmol
targeted mutation 1, Jeffery D Molkentin
MGI:3641543
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Rcan1tm1Jmol/Rcan1tm1Jmol
Rcan2tm1Jmol/Rcan2tm1Jmol 		involves: 129 * C57BL/6 MGI:3652924
cx2
 		Rcan2tm1Jmol/Rcan2tm1Jmol
Tg(Myh6-Ppp3ca)37Eno/0 		involves: 129 * C57BL/6 * FVB MGI:3652922
cx3
 		Rcan1tm1Jmol/Rcan1tm1Jmol
Rcan2tm1Jmol/Rcan2tm1Jmol
Ppp3cbtm1Jmk/Ppp3cbtm1Jmk 		involves: 129S6/SvEvTac * C57BL/6 MGI:3652928


Genotype
MGI:3652924
cx1
Allelic
Composition		 Rcan1tm1Jmol/Rcan1tm1Jmol
Rcan2tm1Jmol/Rcan2tm1Jmol
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rcan1tm1Jmol mutation (1 available); any Rcan1 mutation (26 available)
Rcan2tm1Jmol mutation (1 available); any Rcan2 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal object recognition memory ( J:109586 )
• mice show subtle but significant impairment in working memory assessed by novel and familiar object recognition
hyperactivity ( J:109586 )
• mice show a significant increase in cumulative activity during light and dark conditions

immune system
decreased T cell proliferation ( J:109586 )
• in response to stimulation, total splenocytes show reduced proliferation
abnormal CD4-positive, alpha-beta T cell physiology ( J:109586 )
• after CD3 stimulation, increased apoptosis of CD4+ T cells is observed
abnormal cytokine secretion ( J:109586 )
• in response to stimulation, total splenocytes show reduced proliferation and Il2 production compared to wild-type

cardiovascular system
abnormal myocardium layer morphology ( J:109586 )
• mice do not display cardiac hypertrophy in response to 2 weeks of infusion of phenylephrine plus angiotensin II or 3 weeks of forced exercise unlike wild-type mice
decreased response of heart to induced stress ( J:109586 )
• cardiac function reveals partial protection from pressure overload stimulation decompensation induced by transverse aortic constriction compared to wild-type; cardiac hypertrophy is attenuated
abnormal response to cardiac infarction ( J:109586 )
• myocardial damage is increased in mice after ischemia-reperfusion injury

hematopoietic system
decreased T cell proliferation ( J:109586 )
• in response to stimulation, total splenocytes show reduced proliferation
abnormal CD4-positive, alpha-beta T cell physiology ( J:109586 )
• after CD3 stimulation, increased apoptosis of CD4+ T cells is observed

homeostasis/metabolism
decreased response of heart to induced stress ( J:109586 )
• cardiac function reveals partial protection from pressure overload stimulation decompensation induced by transverse aortic constriction compared to wild-type; cardiac hypertrophy is attenuated
abnormal response to cardiac infarction ( J:109586 )
• myocardial damage is increased in mice after ischemia-reperfusion injury

cellular
decreased T cell proliferation ( J:109586 )
• in response to stimulation, total splenocytes show reduced proliferation

muscle
abnormal myocardium layer morphology ( J:109586 )
• mice do not display cardiac hypertrophy in response to 2 weeks of infusion of phenylephrine plus angiotensin II or 3 weeks of forced exercise unlike wild-type mice




Genotype
MGI:3652922
cx2
Allelic
Composition		 Rcan2tm1Jmol/Rcan2tm1Jmol
Tg(Myh6-Ppp3ca)37Eno/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rcan2tm1Jmol mutation (1 available); any Rcan2 mutation (29 available)
Tg(Myh6-Ppp3ca)37Eno mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased heart weight ( J:109586 )
• at 3 weeks of age, transgenic mice display a ~2-fold increase in heart weight to tibia length ratio compared to non transgenic mice

growth/size/body
increased heart weight ( J:109586 )
• at 3 weeks of age, transgenic mice display a ~2-fold increase in heart weight to tibia length ratio compared to non transgenic mice




Genotype
MGI:3652928
cx3
Allelic
Composition		 Rcan1tm1Jmol/Rcan1tm1Jmol
Rcan2tm1Jmol/Rcan2tm1Jmol
Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3cbtm1Jmk mutation (1 available); any Ppp3cb mutation (67 available)
Rcan1tm1Jmol mutation (1 available); any Rcan1 mutation (26 available)
Rcan2tm1Jmol mutation (1 available); any Rcan2 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
hyperactivity ( J:109586 )
• mice show a significant increase in cumulative activity during light and dark conditions, even greater than that shown in Dscr1/Dscr1l1 knockouts

immune system
decreased T cell proliferation ( J:109586 )
• in response to stimulation, total splenocytes show reduced proliferation
abnormal CD4-positive, alpha beta T cell morphology ( J:109586 )
• T cell development is compromised in triple knockouts compared to wild-type, single or double knockouts; a reduction in number in the spleen is observed
abnormal CD8-positive, alpha beta T cell morphology ( J:109586 )
• T cell development is compromised in triple knockouts compared to wild-type, single or double knockouts; a reduction in number in the spleen is observed
abnormal CD4-positive, alpha-beta T cell physiology ( J:109586 )
• after CD3 stimulation, increased apoptosis of CD4+ T cells is observed
abnormal cytokine secretion ( J:109586 )
• in response to stimulation, total splenocytes show increased Il2 production compared to wild-type

hematopoietic system
decreased T cell proliferation ( J:109586 )
• in response to stimulation, total splenocytes show reduced proliferation
abnormal CD4-positive, alpha beta T cell morphology ( J:109586 )
• T cell development is compromised in triple knockouts compared to wild-type, single or double knockouts; a reduction in number in the spleen is observed
abnormal CD8-positive, alpha beta T cell morphology ( J:109586 )
• T cell development is compromised in triple knockouts compared to wild-type, single or double knockouts; a reduction in number in the spleen is observed
abnormal CD4-positive, alpha-beta T cell physiology ( J:109586 )
• after CD3 stimulation, increased apoptosis of CD4+ T cells is observed

cardiovascular system
decreased response of heart to induced stress ( J:109586 )
• cardiac function reveals partial protection from pressure overload stimulation decompensation induced by transverse aortic constriction compared to wild-type; cardiac hypertrophy is attenuated

homeostasis/metabolism
decreased response of heart to induced stress ( J:109586 )
• cardiac function reveals partial protection from pressure overload stimulation decompensation induced by transverse aortic constriction compared to wild-type; cardiac hypertrophy is attenuated

cellular
decreased T cell proliferation ( J:109586 )
• in response to stimulation, total splenocytes show reduced proliferation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory