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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bfsp1tm1Pgf
targeted mutation 1, Paul G FitzGerald
MGI:3641549
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bfsp1tm1Pgf/Bfsp1tm1Pgf involves: 129P2/OlaHsd * C57BL/6 MGI:3652897
ht2
 		Bfsp1tm1Pgf/Bfsp1+ involves: 129P2/OlaHsd * C57BL/6 MGI:3652898


Genotype
MGI:3652897
hm1
Allelic
Composition		 Bfsp1tm1Pgf/Bfsp1tm1Pgf
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bfsp1tm1Pgf mutation (0 available); any Bfsp1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal lens fiber morphology ( J:109599 )
• beaded filaments are absent from the lens of mutant eyes
cataract ( J:109599 )
• 6-month old homozygotes exhibit stage 3 (on an opacity scale of 1-6) cataracts; subtle opacification is observed at 10 weeks of age and progressively worsens with age




Genotype
MGI:3652898
ht2
Allelic
Composition		 Bfsp1tm1Pgf/Bfsp1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bfsp1tm1Pgf mutation (0 available); any Bfsp1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
cataract ( J:109599 )
• 6-month old heterozygotes show an intermediate phenotype between homozygotes and wild-type, with slight lens opacification in older animals




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory