All Phenotypes Serp1<tm1Hori> MGI Mouse

premature death ( J:109619 )

• ~60% of mice reach adulthood

postnatal lethality, incomplete penetrance ( J:109619 )

• viability of homozygotes declines starting at about 1 week postnatal

• body weights are reduced to 60% of wild-type at 4 weeks

• after 4 weeks growth and body weight steadily increases to ~75% of control weights at 12 weeks of age

decreased circulating insulin level ( J:109619 )

• insulin levels secreted by the pancreas do not increase normally after glucose exposure as in wild-type between 30 to 60 minutes but begins to increase again after 120 minutes

• the production of proinsulin is delayed compared to wild-type

decreased circulating growth hormone level ( J:109619 )

• at 8 weeks in response to hypoglycemia levels do not increase until 60 minutes after insulin infusion whereas in wild-type GH levels peak at 60 minutes; in wild-type levels start to decline at 90 minutes while they continue to increase in mutants

impaired glucose tolerance ( J:109619 )

• between 10 and 20 weeks of age male and female mice display impaired glucose tolerance

small adrenal glands ( J:109619 )

• overall size/mass is reduced up to 60 to 70% compared to wild-type during the neonatal period

small adenohypophysis ( J:109619 )

• at 3 to 8 weeks of age, the anterior lobe is reduced in size compared to wild-type

• the area of the anterior lobe of wild-type is increased 3.6 fold over the posterior and intermediate lobes but in surviving mutants the anterior lobe is increased only 2-fold over the other lobes

small pituitary gland ( J:109619 )

• in dying mutants, the size of the pituitary is reduced even further and cell size is smaller with a reduced cytosol area than that seen in living mutants

small thyroid gland ( J:109619 )