Phenotypes associated with this allele

• Allele Symbol: Tg(CAMK2A-CAST)7Tcs
• Allele Name: transgene insertion 7, Takaomi C Saido
• Allele ID: MGI:3652380
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(CAMK2A-CAST)7Tcs/0	involves: C57BL/6Cr	MGI:3652406

Genotype
MGI:3652406

tg1

• Allelic Composition: Tg(CAMK2A-CAST)7Tcs/0
• Genetic Background: involves: C57BL/6Cr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased susceptibility to neuronal excitotoxicity ( J:98730 , J:109976 )

• overexpression halts excitotoxicity-induced progressive loss of hippocampal neurons after kainate treatment (J:98730)

• shrinkage of neuronal cytoplasm is less severe than in controls, although numbers of pyknotic nuclei did not differ significantly after 24 hours post-kainate treatment (J:98730)

• transgenic mice do not show a decline in numbers of neurons from 24 hours to 7 days as do controls (J:98730)

• dendrites and axons retain their integrities over the course of kainate-induced neuronal degeneration to a greater extent than wild-type non-transgenic controls (J:98730)

• overexpression of calpastatin suppressed appearance of lesions in the hippocampus after kainate treatment (J:109976)

homeostasis/metabolism

decreased susceptibility to neuronal excitotoxicity ( J:98730 , J:109976 )

• overexpression halts excitotoxicity-induced progressive loss of hippocampal neurons after kainate treatment (J:98730)

• shrinkage of neuronal cytoplasm is less severe than in controls, although numbers of pyknotic nuclei did not differ significantly after 24 hours post-kainate treatment (J:98730)

• transgenic mice do not show a decline in numbers of neurons from 24 hours to 7 days as do controls (J:98730)

• dendrites and axons retain their integrities over the course of kainate-induced neuronal degeneration to a greater extent than wild-type non-transgenic controls (J:98730)

• overexpression of calpastatin suppressed appearance of lesions in the hippocampus after kainate treatment (J:109976)

cellular

decreased susceptibility to neuronal excitotoxicity ( J:98730 , J:109976 )

• overexpression halts excitotoxicity-induced progressive loss of hippocampal neurons after kainate treatment (J:98730)

• shrinkage of neuronal cytoplasm is less severe than in controls, although numbers of pyknotic nuclei did not differ significantly after 24 hours post-kainate treatment (J:98730)

• transgenic mice do not show a decline in numbers of neurons from 24 hours to 7 days as do controls (J:98730)

• dendrites and axons retain their integrities over the course of kainate-induced neuronal degeneration to a greater extent than wild-type non-transgenic controls (J:98730)

• overexpression of calpastatin suppressed appearance of lesions in the hippocampus after kainate treatment (J:109976)