Phenotypes associated with this allele

• Allele Symbol: Lta^tm1.1Sned
• Allele Name: targeted mutation 1.1, Sergei A Nedospasov
• Allele ID: MGI:3652393
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lta^tm1.1Sned/Lta^tm1.1Sned	B6.129-Lta^tm1.1Sned	MGI:3652513

Genotype
MGI:3652513

hm1

• Allelic Composition: Lta^tm1.1Sned/Lta^tm1.1Sned
• Genetic Background: B6.129-Lta^tm1.1Sned

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:109621 )

• in response to LPS and D-GalN administration, percentage of severely moribund mice reaches 50% at 7 hours; percentage reaches 100% at 8 hours

• these data are significantly different from that for conventional Lta^tm1Dch mice

immune system

abnormal circulating tumor necrosis factor level ( J:109621 )

• in response to LPS, mice produce wild-type levels of TNF instead of the expected decrease

• bone marrow derived macrophages unexpectedly produce normal levels of TNF when stimulated

abnormal immune system morphology ( J:109621 )

• mice lack all sets of peripheral lymph nodes

enlarged spleen ( J:109621 )

• mice exhibit splenomegaly

abnormal lymphopoiesis ( J:109621 )

• spatial segregation of B and T cells appears more organized than in Lta^tm1Dch knockouts

abnormal class switch recombination ( J:109621 )

• 19 days after immunization with OVA, mice display an isotype switch to IgG from IgM that is several fold decreased compared to wild-type

decreased spleen white pulp amount ( J:109621 )

• white pulp is bigger than in conventional Lta^tm1Dch mice but slightly smaller than wild-type

absent Peyer's patches ( J:109621 )

• these structures are missing

abnormal humoral immune response ( J:109621 )

• antigen-specific IgG response is impaired compared to wild-type but there is some IgG1 production

increased susceptibility to bacterial infection induced morbidity/mortality ( J:109621 )

• in response to LPS and D-GalN administration, percentage of severely moribund mice reaches 50% at 7 hours; percentage reaches 100% at 8 hours

• these data are significantly different from that for conventional Lta^tm1Dch mice

hematopoietic system

enlarged spleen ( J:109621 )

• mice exhibit splenomegaly

abnormal lymphopoiesis ( J:109621 )

• spatial segregation of B and T cells appears more organized than in Lta^tm1Dch knockouts

abnormal class switch recombination ( J:109621 )

• 19 days after immunization with OVA, mice display an isotype switch to IgG from IgM that is several fold decreased compared to wild-type

decreased spleen white pulp amount ( J:109621 )

• white pulp is bigger than in conventional Lta^tm1Dch mice but slightly smaller than wild-type

homeostasis/metabolism

abnormal circulating tumor necrosis factor level ( J:109621 )

• in response to LPS, mice produce wild-type levels of TNF instead of the expected decrease

• bone marrow derived macrophages unexpectedly produce normal levels of TNF when stimulated

growth/size/body

enlarged spleen ( J:109621 )

• mice exhibit splenomegaly