Phenotypes associated with this allele

• Allele Symbol: Clock^tm1.1Rep
• Allele Name: targeted mutation 1.1, Steven M Reppert
• Allele ID: MGI:3652400
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clock^tm1.1Rep/Clock^tm1.1Rep	involves: 129S4/SvJae * C57BL/6J	MGI:3652547

Genotype
MGI:3652547

hm1

• Allelic Composition: Clock^tm1.1Rep/Clock^tm1.1Rep
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal circadian behavior phase ( J:109634 )

• after light-dark entrainment for several weeks (L/D - 12/12 hours) followed by an extension of the light period by 4 hours, wild-type mice and heterozygotes exhibit a phase delay of ~1.6-1.9 hours whereas mutants don't show any delay

advanced circadian behavior phase ( J:109634 )

• mutants become active ~ 2 hours before lights-off (start of dark cycle) while wild-type mice show activity at onset of dark period

• after LD entrainment for 3 weeks, exposure to a light pulse late in the dark phase followed by release into total darkness results in a phase advance of 6.8 hours compared to 1.8-2 hours exhibited by wild-type and heterozygotes in the same paradigm