All Phenotypes Ighg1<tm1(cre)Cgn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ighg1^tm1(cre)Cgn
targeted mutation 1, University of Cologne
MGI:3652526

Summary

27 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm1(gp80,EGFP)Eces}/Gt(ROSA)26Sor⁺ Ighg1^tm1(cre)Cgn/Ighg1⁺	either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)	MGI:5004803
cn2	Ezh2^tm1Tara/Ezh2^tm1Tara Ighg1^tm1(cre)Cgn/Ighg1⁺	involves: 129P2/OlaHsd	MGI:5519931
cn3	Ighg1^tm1(cre)Cgn/Ighg1⁺ Irf4^tm1Rdf/Irf4^tm1.1Rdf	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6	MGI:3712440
cn4	Col1a1^{tm1(CAG-Ezh2*)Meln}/Col1a1⁺ Ighg1^tm1(cre)Cgn/Ighg1⁺	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:5519929
cn5	Gt(ROSA)26Sor^{tm13(CAG-MYC,-CD2*)Rsky}/Gt(ROSA)26Sor⁺ Myc^tm2Fwa/Myc^tm2Fwa Ighg1^tm1(cre)Cgn/Ighg1⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	MGI:5444673
cn6	Gt(ROSA)26Sor^{tm12(CD2*)Rsky}/Gt(ROSA)26Sor⁺ Myc^tm2Fwa/Myc^tm2Fwa Ighg1^tm1(cre)Cgn/Ighg1⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	MGI:5444672
cn7	Ighg1^tm1(cre)Cgn/0 Mef2d^tm3Eno/Mef2d^tm3Eno	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6	MGI:6401161
cn8	Ighg1^tm1(cre)Cgn/0 Mef2b^tm1.1Rdf/Mef2b^tm1.1Rdf Mef2c^tm2Eno/Mef2c^tm2Eno	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6	MGI:6401163
cn9	Ighg1^tm1(cre)Cgn/0 Mef2c^tm2Eno/Mef2c^tm2Eno	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6	MGI:6401159
cn10	Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Ighg1^tm1(cre)Cgn/Ighg1⁺ Prdm1^tm2Masu/Prdm1^tm2Masu	involves: 129P2/OlaHsd * 129X1/SvJ	MGI:5762939
cn11	Gt(ROSA)26Sor^{tm7(Pik3ca,EGFP)Rsky}/Gt(ROSA)26Sor^{tm13(CAG-MYC,-CD2)Rsky} Ighg1^tm1(cre)Cgn/Ighg1⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:5463978
cn12	Mir146^tm1.1Lfl/Mir146^tm1.1Lfl Ighg1^tm1(cre)Cgn/Ighg1⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:6360061
cn13	Ighg1^tm1(cre)Cgn/0 Mef2b^tm1.1Rdf/Mef2b^tm1.1Rdf	involves: 129P2/OlaHsd * C57BL/6	MGI:6401139
cn14	Ighg1^tm1(cre)Cgn/0 Mef2b^tm1.1Rdf/Mef2b⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:6401143
cn15	Ighg1^tm1(cre)Cgn/0 Mef2b^tm2Rdf/Mef2b^tm1.1Rdf	involves: 129P2/OlaHsd * C57BL/6	MGI:6401145
cn16	Ighg1^tm1(cre)Cgn/0 Mef2b^tm2Rdf/Mef2b⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:6401148
cn17	Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky}/Gt(ROSA)26Sor⁺ Ighg1^tm1(cre)Cgn/Ighg1⁺ Prdm1^tm2Masu/Prdm1^tm2Masu	involves: 129P2/OlaHsd * C57BL/6	MGI:5762938
cn18	Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky}/Gt(ROSA)26Sor⁺ Ighg1^tm1(cre)Cgn/Ighg1⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:5762937
cn19	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Ighg1^tm1(cre)Cgn/Ighg1⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:5780068
cn20	Kmt2d^tm1.1Kaig/Kmt2d⁺ Ighg1^tm1(cre)Cgn/Ighg1⁺ Tg(Vav-BCL2)69Jad/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	MGI:5780072
cn21	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Ighg1^tm1(cre)Cgn/Ighg1⁺ Tg(Vav-BCL2)69Jad/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	MGI:5780071
cn22	Bcl6^tm1.1Mtto/Bcl6^tm1.1Mtto Ighg1^tm1(cre)Cgn/Ighg1⁺	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JJcl	MGI:5461329
cn23	Gm614^tm1.1Cya/Gm614^tm1.1Cya Ighg1^tm1(cre)Cgn/Ighg1⁺	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N	MGI:6727909
cn24	Ighg1^tm1(cre)Cgn/Ighg1⁺ Tbl1xr1^{tm1c(EUCOMM)Hmgu}/Tbl1xr1^{tm1c(EUCOMM)Hmgu}	involves: 129P2/OlaHsd * C57BL/6J	MGI:7550774
cn25	Ighg1^tm1(cre)Cgn/Ighg1⁺ Tbl1xr1^tm1.1Meln/Tbl1xr1⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:7550771
cn26	Ighg1^tm1(cre)Cgn/Ighg1⁺ Myd88^em1.1Rsky/Myd88⁺	involves: 129P2/OlaHsd * C57BL/6NTac	MGI:7281484
cn27	Ebf1^tm1.1Rug/Ebf1^tm1.1Rug Ighg1^tm1(cre)Cgn/Ighg1⁺	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5316375

Allelic Composition	Gt(ROSA)26Sor^{tm1(gp80,EGFP)Eces}/Gt(ROSA)26Sor⁺ Ighg1^tm1(cre)Cgn/Ighg1⁺
Genetic Background	either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(gp80,EGFP)Eces} mutation (0 available); any Gt(ROSA)26Sor mutation (985 available)
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Splenomegaly and lack of germinal center formation in Gt(ROSA)26Sor^{tm1(gp80,EGFP)Eces}/Gt(ROSA)26Sor⁺ Cd19^tm1(cre)Cgn/Cd19⁺ (left) and Gt(ROSA)26Sor^{tm1(gp80,EGFP)Eces}/Gt(ROSA)26Sor⁺ Ighg1^tm1(cre)Cgn/Ighg1⁺ mice (right)

growth/size/body

enlarged spleen ( J:172031 )

• in non-immunized and immunized mice starting at 2 to 3 months of age

increased spleen weight ( J:172031 )

mortality/aging

decreased tumor-free survival time ( J:172031 )

• mice succumb to tumors between 7 and 19 months of age

immune system

enlarged spleen ( J:172031 )

• in non-immunized and immunized mice starting at 2 to 3 months of age

increased spleen weight ( J:172031 )

abnormal class switch recombination ( J:172031 )

decreased B cell number ( J:172031 )

• mice exhibit fewer IgG1+ B cells compared to in wild-type mice

decreased germinal center B cell number ( J:172031 )

decreased follicular B cell number ( J:172031 )

decreased plasma cell number ( J:172031 )

increased B cell number ( J:172031 )

• in the spleen with a slight reduction in the splenic B to T cell ratio

increased marginal zone B cell number ( J:172031 )

increased macrophage cell number ( J:172031 )

absent spleen germinal center ( J:172031 )

• in non-immunized and immunized mice

decreased IgA level ( J:172031 )

• NP-stimulated

increased IgE level ( J:172031 )

• resting and NP-stimulated

decreased IgG1 level ( J:172031 )

• resting and NP-stimulated

decreased IgG2a level ( J:172031 )

• resting and NP-stimulated

decreased IgG2b level ( J:172031 )

• resting and NP-stimulated

decreased IgG3 level ( J:172031 )

• resting and NP-stimulated

neoplasm

increased tumor incidence ( J:172031 )

• mice develop tumors in lymphoid tissues including nasopharynx, armpit, and inguinal region

increased sarcoma incidence ( J:172031 )

• histocytic/dendritic cell sarcoma

increased histiocytic sarcoma incidence ( J:172031 )

hematopoietic system

enlarged spleen ( J:172031 )

• in non-immunized and immunized mice starting at 2 to 3 months of age

increased spleen weight ( J:172031 )

abnormal class switch recombination ( J:172031 )

decreased B cell number ( J:172031 )

• mice exhibit fewer IgG1+ B cells compared to in wild-type mice

decreased germinal center B cell number ( J:172031 )

decreased follicular B cell number ( J:172031 )

decreased plasma cell number ( J:172031 )

increased B cell number ( J:172031 )

• in the spleen with a slight reduction in the splenic B to T cell ratio

increased marginal zone B cell number ( J:172031 )

increased macrophage cell number ( J:172031 )

absent spleen germinal center ( J:172031 )

• in non-immunized and immunized mice

decreased IgA level ( J:172031 )

• NP-stimulated

increased IgE level ( J:172031 )

• resting and NP-stimulated

decreased IgG1 level ( J:172031 )

• resting and NP-stimulated

decreased IgG2a level ( J:172031 )

• resting and NP-stimulated

decreased IgG2b level ( J:172031 )

• resting and NP-stimulated

decreased IgG3 level ( J:172031 )

• resting and NP-stimulated

Allelic Composition	Ezh2^tm1Tara/Ezh2^tm1Tara Ighg1^tm1(cre)Cgn/Ighg1⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh2^tm1Tara mutation (2 available); any Ezh2 mutation (71 available)
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:199122 )

N	• mice exhibit normal marginal zone and follicular B cells

decreased B cell proliferation ( J:199122 )

• reduced germinal center B cell compartment proliferation following injection of antigen sheep red blood cells

decreased germinal center B cell number ( J:199122 )

• following injection of antigen sheep red blood cells or immunization with NP-KLH

decreased spleen germinal center number ( J:199122 )

• following injection of antigen sheep red blood cells

decreased spleen germinal center size ( J:199122 )

• following injection of antigen sheep red blood cells

decreased IgG1 level ( J:199122 )

• following immunization with NP-KLH

decreased IgG2b level ( J:199122 )

• following immunization with NP-KLH

decreased IgG3 level ( J:199122 )

• following immunization with NP-KLH

hematopoietic system

decreased B cell proliferation ( J:199122 )

• reduced germinal center B cell compartment proliferation following injection of antigen sheep red blood cells

decreased germinal center B cell number ( J:199122 )

• following injection of antigen sheep red blood cells or immunization with NP-KLH

decreased spleen germinal center number ( J:199122 )

• following injection of antigen sheep red blood cells

decreased spleen germinal center size ( J:199122 )

• following injection of antigen sheep red blood cells

decreased IgG1 level ( J:199122 )

• following immunization with NP-KLH

decreased IgG2b level ( J:199122 )

• following immunization with NP-KLH

decreased IgG3 level ( J:199122 )

• following immunization with NP-KLH

cellular

decreased B cell proliferation ( J:199122 )

• reduced germinal center B cell compartment proliferation following injection of antigen sheep red blood cells

Allelic Composition	Ighg1^tm1(cre)Cgn/Ighg1⁺ Irf4^tm1Rdf/Irf4^tm1.1Rdf
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (27 available)
Irf4^tm1.1Rdf mutation (0 available); any Irf4 mutation (27 available)
Irf4^tm1Rdf mutation (1 available); any Irf4 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:112643 )

N	• mice form germinal centers and have similar numbers of PNA^hi, B220+ B cells in spleen

abnormal class switch recombination ( J:112643 )

• following CD40 and Il-4 stimulation, mice have smaller fraction of class-switched cells than control mice (7.4% vs 26.3%); defect appears to be downstream of Cgamma1 germline transcription

absent plasma cells ( J:112643 )

• 14 days after immunization with sheep red blood cells, mutants are observed to lack plasma cells, as recognized by CD138 expression, in spleen, peripheral blood and bone marrow

abnormal memory B cell morphology ( J:112643 )

• memory B cell generation occurs in mutants after immunization with NP-KLH, but the population is maintained only partly over time; numbers of NP-binding cells are much lower 42 days after immunization compared to controls

• mice receiving a secondary immunization with antigen lack plasmablasts in the spleen that bind NP, are CD138 +ve and have low B220 expression, indicating that memory B cells cannot differentiate into plasma B cells upon antigen restimulation; B cells also lack IgG1 secretion after restimulation

decreased IgG1 level ( J:112643 )

• mice have much lower titer of IgG1 specific for the hapten NP (nitrophenylacetyl) than controls after immunization with NP coupled to keyhole limpet hemocyanin, but titers of other immunoglobulin classes are similar to levels in controls

hematopoietic system

abnormal class switch recombination ( J:112643 )

• following CD40 and Il-4 stimulation, mice have smaller fraction of class-switched cells than control mice (7.4% vs 26.3%); defect appears to be downstream of Cgamma1 germline transcription

absent plasma cells ( J:112643 )

• 14 days after immunization with sheep red blood cells, mutants are observed to lack plasma cells, as recognized by CD138 expression, in spleen, peripheral blood and bone marrow

abnormal memory B cell morphology ( J:112643 )

decreased IgG1 level ( J:112643 )

Allelic Composition	Col1a1^{tm1(CAG-Ezh2*)Meln}/Col1a1⁺ Ighg1^tm1(cre)Cgn/Ighg1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1^{tm1(CAG-Ezh2*)Meln} mutation (0 available); any Col1a1 mutation (161 available)
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:199122 )

N	• mice exhibit normal marginal zone and follicular B cells

increased germinal center B cell number ( J:199122 )

• following immunization with NP-KLH

increased spleen germinal center number ( J:199122 )

• following immunization with NP-KLH

increased spleen germinal center size ( J:199122 )

• following immunization with NP-KLH

neoplasm

neoplasm ( J:199122 )

N	• mice exhibit normal marginal zone and follicular B cells

hematopoietic system

increased germinal center B cell number ( J:199122 )

• following immunization with NP-KLH

increased spleen germinal center number ( J:199122 )

• following immunization with NP-KLH

increased spleen germinal center size ( J:199122 )

• following immunization with NP-KLH

Allelic Composition	Gt(ROSA)26Sor^{tm13(CAG-MYC,-CD2*)Rsky}/Gt(ROSA)26Sor⁺ Myc^tm2Fwa/Myc^tm2Fwa Ighg1^tm1(cre)Cgn/Ighg1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm13(CAG-MYC,-CD2*)Rsky} mutation (1 available); any Gt(ROSA)26Sor mutation (985 available)
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (27 available)
Myc^tm2Fwa mutation (2 available); any Myc mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:188564 )

N	• enforced expression of human MYC rescues germinal center formation

Allelic Composition	Gt(ROSA)26Sor^{tm12(CD2*)Rsky}/Gt(ROSA)26Sor⁺ Myc^tm2Fwa/Myc^tm2Fwa Ighg1^tm1(cre)Cgn/Ighg1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm12(CD2*)Rsky} mutation (0 available); any Gt(ROSA)26Sor mutation (985 available)
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (27 available)
Myc^tm2Fwa mutation (2 available); any Myc mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased spleen germinal center size ( J:188564 )

• almost complete ablation of germinal centers in response to T cell dependent immunization

• the few remaining germinal center B cells have escaped cre mediated recombination

hematopoietic system

decreased spleen germinal center size ( J:188564 )

• almost complete ablation of germinal centers in response to T cell dependent immunization

• the few remaining germinal center B cells have escaped cre mediated recombination

Allelic Composition	Ighg1^tm1(cre)Cgn/0 Mef2d^tm3Eno/Mef2d^tm3Eno
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (27 available)
Mef2d^tm3Eno mutation (0 available); any Mef2d mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:265465 )

N	• normal spleen germinal center (GC) B cell numbers 14 days after immunization with sheep red blood cells (SRBCs)

Allelic Composition	Ighg1^tm1(cre)Cgn/0 Mef2b^tm1.1Rdf/Mef2b^tm1.1Rdf Mef2c^tm2Eno/Mef2c^tm2Eno
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (27 available)
Mef2b^tm1.1Rdf mutation (0 available); any Mef2b mutation (22 available)
Mef2c^tm2Eno mutation (0 available); any Mef2c mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased germinal center B cell number ( J:265465 )

• 14 days after immunization with sheep red blood cells (SRBCs)

immune system

decreased germinal center B cell number ( J:265465 )

• 14 days after immunization with sheep red blood cells (SRBCs)

Allelic Composition	Ighg1^tm1(cre)Cgn/0 Mef2c^tm2Eno/Mef2c^tm2Eno
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (27 available)
Mef2c^tm2Eno mutation (0 available); any Mef2c mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased germinal center B cell number ( J:265465 )

• 14 days after immunization with sheep red blood cells (SRBCs)

immune system

decreased germinal center B cell number ( J:265465 )

• 14 days after immunization with sheep red blood cells (SRBCs)

Allelic Composition	Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Ighg1^tm1(cre)Cgn/Ighg1⁺ Prdm1^tm2Masu/Prdm1^tm2Masu
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(EYFP)Cos mutation (12 available); any Gt(ROSA)26Sor mutation (985 available)
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (27 available)
Prdm1^tm2Masu mutation (1 available); any Prdm1 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

enlarged spleen ( J:167612 )

• splenomegaly in all terminally ill mice

abnormal plasma cell differentiation ( J:167612 )

• plasma cell formation is severely impeded 10 days after primary and secondary immunization

increased germinal center B cell number ( J:167612 )

• mice show increased numbers of germinal center B cells at day 10 after primary immunizations

abnormal germinal center B cell physiology ( J:167612 )

• small, but significant, increase of the fraction of germinal center B cells in the S and G2 phases of the cell cycle

decreased IgG1 level ( J:167612 )

• reduction in total as well as sheep red blood cell-specific IgG1, but not IgM, antibodies 10 days after primary and secondary immunization

immune system

enlarged spleen ( J:167612 )

• splenomegaly in all terminally ill mice

abnormal plasma cell differentiation ( J:167612 )

• plasma cell formation is severely impeded 10 days after primary and secondary immunization

increased germinal center B cell number ( J:167612 )

• mice show increased numbers of germinal center B cells at day 10 after primary immunizations

abnormal germinal center B cell physiology ( J:167612 )

• small, but significant, increase of the fraction of germinal center B cells in the S and G2 phases of the cell cycle

decreased IgG1 level ( J:167612 )

• reduction in total as well as sheep red blood cell-specific IgG1, but not IgM, antibodies 10 days after primary and secondary immunization

enlarged lymph nodes ( J:167612 )

• occasional lymphadenopathy

liver/biliary system

enlarged liver ( J:167612 )

• hepatomegaly in one mouse

mortality/aging

decreased survivor rate ( J:167612 )

• shortened survival

premature death ( J:167612 )

• shortened survival

neoplasm

increased B cell derived lymphoma incidence ( J:167612 )

• spleens and lymph nodes show presence of large cells with a diffuse growth pattern, resembling diffuse large B cell lymphoma (DLBCL)

• lymphoproliferations are of clonal origin

• 5 of 6 DLBCLs are consistent with activated B cell-DLBCL

growth/size/body

enlarged liver ( J:167612 )

• hepatomegaly in one mouse

enlarged spleen ( J:167612 )

• splenomegaly in all terminally ill mice

Allelic Composition	Gt(ROSA)26Sor^{tm7(Pik3ca,EGFP)Rsky}/Gt(ROSA)26Sor^{tm13(CAG-MYC,-CD2)Rsky} Ighg1^tm1(cre)Cgn/Ighg1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm13(CAG-MYC,-CD2*)Rsky} mutation (1 available); any Gt(ROSA)26Sor mutation (985 available)
Gt(ROSA)26Sor^{tm7(Pik3ca*,EGFP)Rsky} mutation (1 available); any Gt(ROSA)26Sor mutation (985 available)
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:191824 )

• when bone marrow is used to reconstitute Rag2 and Il2rg null mice stimulated with sheep red blood cells, median survival is 227 days

immune system

abnormal class switch recombination ( J:191824 )

• impaired

increased germinal center B cell number ( J:191824 )

• in the Peyer's patches and spleen

neoplasm

increased B cell derived lymphoma incidence ( J:191824 )

• of germinal center B cell origin when bone marrow is used to reconstitute Rag2 and Il2rg null mice stimulated with sheep red blood cells

hematopoietic system

abnormal class switch recombination ( J:191824 )

• impaired

increased germinal center B cell number ( J:191824 )

• in the Peyer's patches and spleen

Allelic Composition	Mir146^tm1.1Lfl/Mir146^tm1.1Lfl Ighg1^tm1(cre)Cgn/Ighg1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (27 available)
Mir146^tm1.1Lfl mutation (1 available); any Mir146 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased germinal center B cell number ( J:266124 )

• mild day 28 post immunization with sheep red blood cells

increased T follicular helper cell number ( J:266124 )

• mild day 28 post immunization with sheep red blood cells

hematopoietic system

increased germinal center B cell number ( J:266124 )

• mild day 28 post immunization with sheep red blood cells

increased T follicular helper cell number ( J:266124 )

• mild day 28 post immunization with sheep red blood cells

Allelic Composition	Ighg1^tm1(cre)Cgn/0 Mef2b^tm1.1Rdf/Mef2b^tm1.1Rdf
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal mature B cell morphology ( J:265465 )

• decreased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)

• smaller GC B cells 10 days after immunization with sheep red blood cells (SRBCs)

• normal follicular and marginal zone B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)

decreased germinal center B cell number ( J:265465 )

• 10 days after immunization with sheep red blood cells (SRBCs)

• reduced dark zone (DZ)/light zone (LZ) ratio owing to reduced number of cells in DZ

immune system

abnormal mature B cell morphology ( J:265465 )

• decreased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)

• smaller GC B cells 10 days after immunization with sheep red blood cells (SRBCs)

• normal follicular and marginal zone B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)

decreased germinal center B cell number ( J:265465 )

• 10 days after immunization with sheep red blood cells (SRBCs)

• reduced dark zone (DZ)/light zone (LZ) ratio owing to reduced number of cells in DZ

Allelic Composition	Ighg1^tm1(cre)Cgn/0 Mef2b^tm1.1Rdf/Mef2b⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased germinal center B cell number ( J:265465 )

• modest reduction in number 10 days after immunization with sheep red blood cells (SRBCs)

• reduced dark zone (DZ)/light zone (LZ) ratio owing to reduced number of cells in DZ

immune system

decreased germinal center B cell number ( J:265465 )

• modest reduction in number 10 days after immunization with sheep red blood cells (SRBCs)

• reduced dark zone (DZ)/light zone (LZ) ratio owing to reduced number of cells in DZ

Allelic Composition	Ighg1^tm1(cre)Cgn/0 Mef2b^tm2Rdf/Mef2b^tm1.1Rdf
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (27 available)
Mef2b^tm1.1Rdf mutation (0 available); any Mef2b mutation (22 available)
Mef2b^tm2Rdf mutation (0 available); any Mef2b mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal mature B cell morphology ( J:265465 )

• increased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)

• larger GC B cells 10 days after immunization with sheep red blood cells (SRBCs)

• normal non-GC B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)

increased germinal center B cell number ( J:265465 )

• 10 days after immunization with sheep red blood cells (SRBCs)

immune system

abnormal mature B cell morphology ( J:265465 )

• increased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)

• larger GC B cells 10 days after immunization with sheep red blood cells (SRBCs)

• normal non-GC B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)

increased germinal center B cell number ( J:265465 )

• 10 days after immunization with sheep red blood cells (SRBCs)

Allelic Composition	Ighg1^tm1(cre)Cgn/0 Mef2b^tm2Rdf/Mef2b⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (27 available)
Mef2b^tm2Rdf mutation (0 available); any Mef2b mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal mature B cell morphology ( J:265465 )

• increased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)

• larger GC B cells 10 days after immunization with sheep red blood cells (SRBCs)

• normal non-GC B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)

increased germinal center B cell number ( J:265465 )

• 10 days after immunization with sheep red blood cells (SRBCs)

• reduced dark zone (DZ)/light zone (LZ) ratio owing to reduced number of cells in DZ and increased number in LZ

immune system

abnormal mature B cell morphology ( J:265465 )

• increased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)

• larger GC B cells 10 days after immunization with sheep red blood cells (SRBCs)

• normal non-GC B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)

increased germinal center B cell number ( J:265465 )

• 10 days after immunization with sheep red blood cells (SRBCs)

• reduced dark zone (DZ)/light zone (LZ) ratio owing to reduced number of cells in DZ and increased number in LZ

Allelic Composition	Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky}/Gt(ROSA)26Sor⁺ Ighg1^tm1(cre)Cgn/Ighg1⁺ Prdm1^tm2Masu/Prdm1^tm2Masu
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky} mutation (2 available); any Gt(ROSA)26Sor mutation (985 available)
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (27 available)
Prdm1^tm2Masu mutation (1 available); any Prdm1 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal plasma cell differentiation ( J:167612 )

• plasma cell formation is severely impeded 10 days after primary and secondary immunization

increased germinal center B cell number ( J:167612 )

• mice show increased numbers of germinal center B cells at day 10 after primary immunizations

abnormal germinal center B cell physiology ( J:167612 )

• small, but significant, increase of the fraction of germinal center B cells in the S and G2 phases of the cell cycle

decreased IgG1 level ( J:167612 )

• reduction in total as well as sheep red blood cell-specific IgG1, but not IgM, antibodies 10 days after primary and secondary immunization

immune system

abnormal plasma cell differentiation ( J:167612 )

• plasma cell formation is severely impeded 10 days after primary and secondary immunization

increased germinal center B cell number ( J:167612 )

• mice show increased numbers of germinal center B cells at day 10 after primary immunizations

abnormal germinal center B cell physiology ( J:167612 )

• small, but significant, increase of the fraction of germinal center B cells in the S and G2 phases of the cell cycle

decreased IgG1 level ( J:167612 )

• reduction in total as well as sheep red blood cell-specific IgG1, but not IgM, antibodies 10 days after primary and secondary immunization

mortality/aging

decreased survivor rate ( J:167612 )

premature death ( J:167612 )

• shortened survival, with 40% survival at around 500 days of age

neoplasm

increased B cell derived lymphoma incidence ( J:167612 )

• mice succumb to a B cell-derived lymphoproliferative disease affecting spleen and lymph nodes, resembling human diffuse large B cell lymphoma

• mice develop clonal lymphomas consistent with activated B cell-diffuse large B cell lymphoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
non-Hodgkin lymphoma		DOID:0060060	OMIM:605027	J:167612

Allelic Composition	Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky}/Gt(ROSA)26Sor⁺ Ighg1^tm1(cre)Cgn/Ighg1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased germinal center B cell number ( J:167612 )

• mice show some reduction in the germinal center B cell fraction at day 10 after primary and secondary immunization

increased B cell number ( J:167612 )

• hyperplasia of B cells in the spleen and bone marrow at 550-600 days

increased plasma cell number ( J:167612 )

• hyperplasia of plasma cells in the spleen and bone marrow at 550-600 days

• clonal or oligoclonal plasma cell expansions

abnormal spleen morphology ( J:167612 )

• large numbers of cells expressing intracellular Ig and the plasma cell marker CD138 are seen in spleens

enlarged spleen ( J:167612 )

• enlarged spleens in mice 550-600 days of age

increased IgG1 level ( J:167612 )

increased IgM level ( J:167612 )

immune system

decreased germinal center B cell number ( J:167612 )

• mice show some reduction in the germinal center B cell fraction at day 10 after primary and secondary immunization

increased B cell number ( J:167612 )

• hyperplasia of B cells in the spleen and bone marrow at 550-600 days

increased plasma cell number ( J:167612 )

• hyperplasia of plasma cells in the spleen and bone marrow at 550-600 days

• clonal or oligoclonal plasma cell expansions

abnormal spleen morphology ( J:167612 )

• large numbers of cells expressing intracellular Ig and the plasma cell marker CD138 are seen in spleens

enlarged spleen ( J:167612 )

• enlarged spleens in mice 550-600 days of age

increased IgG1 level ( J:167612 )

increased IgM level ( J:167612 )

growth/size/body

enlarged spleen ( J:167612 )

• enlarged spleens in mice 550-600 days of age

Allelic Composition	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Ighg1^tm1(cre)Cgn/Ighg1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (27 available)
Kmt2d^tm1.1Kaig mutation (1 available); any Kmt2d mutation (168 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:228913 )

N	• unimmunized mice exhibit normal germinal center size and number, IgG1+ B cell numbers, plasma cells, total IgG1 serum levels and induced B cell proliferation

Allelic Composition	Kmt2d^tm1.1Kaig/Kmt2d⁺ Ighg1^tm1(cre)Cgn/Ighg1⁺ Tg(Vav-BCL2)69Jad/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:228913 )

• mice die around 13 months of age as in Tg(Vav-BCL2)1Jad mice

neoplasm

increased B cell derived lymphoma incidence ( J:228913 )

• diffuse large B cell lymphoma as in Tg(Vav-BCL2)1Jad mice

increased follicular lymphoma incidence ( J:228913 )

• more so than in Tg(Vav-BCL2)1Jad mice

Allelic Composition	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Ighg1^tm1(cre)Cgn/Ighg1⁺ Tg(Vav-BCL2)69Jad/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:228913 )

• mice die around 13 months of age as in Tg(Vav-BCL2)1Jad mice

neoplasm

increased B cell derived lymphoma incidence ( J:228913 )

• diffuse large B cell lymphoma more so than in Tg(Vav-BCL2)1Jad mice

increased follicular lymphoma incidence ( J:228913 )

• more so than in Tg(Vav-BCL2)1Jad mice

Allelic Composition	Bcl6^tm1.1Mtto/Bcl6^tm1.1Mtto Ighg1^tm1(cre)Cgn/Ighg1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6^tm1.1Mtto mutation (1 available); any Bcl6 mutation (55 available)
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:190943 )

N	• mice immunized with NP-CG exhibit normal development of memory B cells

decreased germinal center B cell number ( J:190943 )

• in mice immunized with NP-CG at day 7 and 40 with deletion of early GC B cells

hematopoietic system

decreased germinal center B cell number ( J:190943 )

• in mice immunized with NP-CG at day 7 and 40 with deletion of early GC B cells

Allelic Composition	Gm614^tm1.1Cya/Gm614^tm1.1Cya Ighg1^tm1(cre)Cgn/Ighg1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gm614^tm1.1Cya mutation (0 available); any Gm614 mutation (5 available)
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:307345 )

N	• normal total IgG levels after pristane injection • normal CD86^loCXCR4^hi dark zone (DZ) and CD86^hiCXCR4^lo light zone (LZ) B cells ratio after pristane injection • normal B cell cell cycle after pristane injection

increased B cell apoptosis ( J:307345 )

• in germinal center after pristane injection

decreased susceptibility to systemic lupus erythematosus ( J:307345 )

• reduced inflammatory cell infiltration in kidney and normal glomerular morphology after pristane injection

• reduced levels of IgM and IgG anti-nucleic antibodies and anti-nucleosome IgG after pristane injection

hematopoietic system

increased B cell apoptosis ( J:307345 )

• in germinal center after pristane injection

cellular

increased B cell apoptosis ( J:307345 )

• in germinal center after pristane injection

Allelic Composition	Ighg1^tm1(cre)Cgn/Ighg1⁺ Tbl1xr1^{tm1c(EUCOMM)Hmgu}/Tbl1xr1^{tm1c(EUCOMM)Hmgu}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (27 available)
Tbl1xr1^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Tbl1xr1 mutation (321 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:292118 )

• decreased number and proportion of FAS+ GL7+and FAS+ CD38- germinal center B cells (GCBs) after immunization with sheep red blood cells (SRBC)

• normal B cell abundance

abnormal spleen morphology ( J:292118 )

• smaller germinal centers (GCs) after immunization with sheep red blood cells (SRBC)

• normal follicular structure and number of GCs after immunization with sheep red blood cells (SRBC)

immune system

abnormal B cell differentiation ( J:292118 )

• decreased number and proportion of FAS+ GL7+and FAS+ CD38- germinal center B cells (GCBs) after immunization with sheep red blood cells (SRBC)

• normal B cell abundance

abnormal spleen morphology ( J:292118 )

• smaller germinal centers (GCs) after immunization with sheep red blood cells (SRBC)

• normal follicular structure and number of GCs after immunization with sheep red blood cells (SRBC)

Allelic Composition	Ighg1^tm1(cre)Cgn/Ighg1⁺ Tbl1xr1^tm1.1Meln/Tbl1xr1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (27 available)
Tbl1xr1^tm1.1Meln mutation (0 available); any Tbl1xr1 mutation (321 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:292118 )

• decreased number and proportion of FAS+ GL7+and FAS+ CD38- germinal center B cells (GCBs) after immunization with sheep red blood cells (SRBC)

• normal B cell abundance

abnormal spleen morphology ( J:292118 )

• smaller germinal centers (GCs) after immunization with sheep red blood cells (SRBC)

• normal follicular structure and number of GCs after immunization with sheep red blood cells (SRBC)

immune system

abnormal B cell differentiation ( J:292118 )

• decreased number and proportion of FAS+ GL7+and FAS+ CD38- germinal center B cells (GCBs) after immunization with sheep red blood cells (SRBC)

• normal B cell abundance

abnormal spleen morphology ( J:292118 )

• smaller germinal centers (GCs) after immunization with sheep red blood cells (SRBC)

• normal follicular structure and number of GCs after immunization with sheep red blood cells (SRBC)

Allelic Composition	Ighg1^tm1(cre)Cgn/Ighg1⁺ Myd88^em1.1Rsky/Myd88⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (27 available)
Myd88^em1.1Rsky mutation (0 available); any Myd88 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:308792 )

N	• normal Ig class switching in germinal center B cells after immunization with hapten-carrier conjugate NP-CGG • normal rise and fall of hapten-specific IgG levels after immunization with hapten-carrier conjugate NP-CGG

abnormal somatic hypermutation frequency ( J:308792 )

• increased frequency in IgM+ plasma cells

increased germinal center B cell number ( J:308792 )

• increased frequency and number

increased plasma cell number ( J:308792 )

• persistently high number of hapten-specific IgM+ plasma cells in spleen and bone marrow for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

• high total plasma cell numbers in spleen and bone marrow for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

abnormal splenic cell ratio ( J:308792 )

• increased frequency and number of plasma cells and germinal center B cells

increased IgM level ( J:308792 )

• high total IgM serum levels for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

• persistently high hapten-specific IgM levels for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

immune system

abnormal somatic hypermutation frequency ( J:308792 )

• increased frequency in IgM+ plasma cells

increased germinal center B cell number ( J:308792 )

• increased frequency and number

increased plasma cell number ( J:308792 )

• persistently high number of hapten-specific IgM+ plasma cells in spleen and bone marrow for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

• high total plasma cell numbers in spleen and bone marrow for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

abnormal splenic cell ratio ( J:308792 )

• increased frequency and number of plasma cells and germinal center B cells

increased IgM level ( J:308792 )

• high total IgM serum levels for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

• persistently high hapten-specific IgM levels for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
monoclonal gammopathy of uncertain significance		DOID:7442		J:308792

Allelic Composition	Ebf1^tm1.1Rug/Ebf1^tm1.1Rug Ighg1^tm1(cre)Cgn/Ighg1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf1^tm1.1Rug mutation (0 available); any Ebf1 mutation (73 available)
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased germinal center B cell number ( J:182210 )

• 2 to 3 times in immunized mice

hematopoietic system

decreased germinal center B cell number ( J:182210 )

• 2 to 3 times in immunized mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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