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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Myh6tm1Rbns
targeted mutation 1, Jeffrey Robbins
MGI:3652543
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Myh6tm1Rbns/Myh6tm1Rbns involves: 129P2/OlaHsd MGI:3652797
ht2
Myh6tm1Rbns/Myh6+ involves: 129P2/OlaHsd MGI:3652799


Genotype
MGI:3652797
hm1
Allelic
Composition
Myh6tm1Rbns/Myh6tm1Rbns
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh6tm1Rbns mutation (0 available); any Myh6 mutation (206 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes die in utero between E11-12.5 of gross heart defects




Genotype
MGI:3652799
ht2
Allelic
Composition
Myh6tm1Rbns/Myh6+
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh6tm1Rbns mutation (0 available); any Myh6 mutation (206 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Fibrotic lesions in Myh6tm1Rbns/Myh6+ hearts

cardiovascular system
• the average length of myofibrils is ~50% that of control lengths; the A bands of myofibrils occupy the entire sarcomeric length and I bands cant't be detected; A band length is reduced by approximately 75% relative to controls
• mutant sarcomeres are only 79% as long as controls
• myofibrils display numerous areas where thin filaments are absent compared to controls which have regular hexameric arrays of thick and thin filaments
• some of the heterozygotes (3/8) appear to have hypertrophy of the ventricular walls associated with occlusion of the left ventricular chamber
• many hearts show multifocal areas of fibrosis, most commonly in the apex and left ventricular wall; fibrosis is also frequently seen in the right ventricle and interventricular septum
• mutants display increased time to peak pressure, indicative of reduced contractility
• mutant hearts have diastolic IVPs that are 9mm Hg higher than wild-type
• mutant hearts have systolic IVPs that are 14mm Hg lower than wild-type

muscle
• the average length of myofibrils is ~50% that of control lengths; the A bands of myofibrils occupy the entire sarcomeric length and I bands cant't be detected; A band length is reduced by approximately 75% relative to controls
• mutant sarcomeres are only 79% as long as controls
• myofibrils display numerous areas where thin filaments are absent compared to controls which have regular hexameric arrays of thick and thin filaments
• mutants display increased time to peak pressure, indicative of reduced contractility





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory