mortality/aging
• homozygotes die in utero between E11-12.5 of gross heart defects
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Allele Symbol Allele Name Allele ID |
Myh6tm1Rbns targeted mutation 1, Jeffrey Robbins MGI:3652543 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• homozygotes die in utero between E11-12.5 of gross heart defects
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• the average length of myofibrils is ~50% that of control lengths; the A bands of myofibrils occupy the entire sarcomeric length and I bands cant't be detected; A band length is reduced by approximately 75% relative to controls
• mutant sarcomeres are only 79% as long as controls
• myofibrils display numerous areas where thin filaments are absent compared to controls which have regular hexameric arrays of thick and thin filaments
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• some of the heterozygotes (3/8) appear to have hypertrophy of the ventricular walls associated with occlusion of the left ventricular chamber
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• many hearts show multifocal areas of fibrosis, most commonly in the apex and left ventricular wall; fibrosis is also frequently seen in the right ventricle and interventricular septum
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• mutants display increased time to peak pressure, indicative of reduced contractility
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• mutant hearts have diastolic IVPs that are 9mm Hg higher than wild-type
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• mutant hearts have systolic IVPs that are 14mm Hg lower than wild-type
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• the average length of myofibrils is ~50% that of control lengths; the A bands of myofibrils occupy the entire sarcomeric length and I bands cant't be detected; A band length is reduced by approximately 75% relative to controls
• mutant sarcomeres are only 79% as long as controls
• myofibrils display numerous areas where thin filaments are absent compared to controls which have regular hexameric arrays of thick and thin filaments
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• mutants display increased time to peak pressure, indicative of reduced contractility
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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