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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igkctm1Bgmn
targeted mutation 1, Marianne Bruggemann
MGI:3652576
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Igkctm1Bgmn/Igkctm1Bgmn involves: 129P2/OlaHsd MGI:3652818
cx2
 		Ighmtm1Cgn/Ighmtm1Cgn
Igkctm1Bgmn/Igkctm1Bgmn
Igltm2.1Bgmn/Igltm2.1Bgmn 		involves: 129 MGI:3806699
cx3
 		Igkctm1Bgmn/Igkctm1Bgmn
Igltm2.1Bgmn/Igltm2.1Bgmn 		involves: 129P2/OlaHsd MGI:3806697
cx4
 		Ighmtm3Bgmn/Ighmtm3Bgmn
Igkctm1Bgmn/Igkctm1Bgmn
Igltm2.1Bgmn/Igltm2.1Bgmn 		involves: 129P2/OlaHsd * 129/Sv MGI:3806698
cx5
 		Igkctm1Bgmn/Igkctm1Bgmn
Igltm1.1Bgmn/Igltm1.1Bgmn 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA MGI:3702894
cx6
 		Igkctm1Bgmn/Igkctm1Bgmn
Igltm1Bgmn/Igltm1Bgmn 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA MGI:3702900
cx7
 		Igkctm1Bgmn/Igkctm1Bgmn
Igltm2Bgmn/Igltm2Bgmn 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA MGI:3702901
cx8
 		Igkctm1Bgmn/Igkctm1Bgmn
Igltm2.1Bgmn/Igltm2.1Bgmn 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA MGI:3702904


Genotype
MGI:3652818
hm1
Allelic
Composition		 Igkctm1Bgmn/Igkctm1Bgmn
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkctm1Bgmn mutation (0 available); any Igkc mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell number ( J:28868 , J:118712 )
• there are higher numbers of CD45R(B220)+ putative B cells in the Peyer's Patches compared to controls, despite reduced total cellularity (J:28868)
• at stage when L chain rearrangement should have been completed, number of IgM+ B220+ cells (0.4 x 106) in bone marrow is reduced by >50% compared to normal mice (J:118712)
abnormal Peyer's patch morphology ( J:28868 )
• in mutants PPs have a dramatically reduced cell content compared to controls
abnormal Peyer's patch germinal center morphology ( J:28868 )
• there are small but highly active germinal centers
abnormal humoral immune response ( J:28868 )
• after immunization with antigens which elicit a restricted response in normal mice, there is an elevated antibody titer but mice display no titer increase after secondary challenge

hematopoietic system
abnormal B cell number ( J:28868 , J:118712 )
• there are higher numbers of CD45R(B220)+ putative B cells in the Peyer's Patches compared to controls, despite reduced total cellularity (J:28868)
• at stage when L chain rearrangement should have been completed, number of IgM+ B220+ cells (0.4 x 106) in bone marrow is reduced by >50% compared to normal mice (J:118712)




Genotype
MGI:3806699
cx2
Allelic
Composition		 Ighmtm1Cgn/Ighmtm1Cgn
Igkctm1Bgmn/Igkctm1Bgmn
Igltm2.1Bgmn/Igltm2.1Bgmn
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Cgn mutation (17 available); any Ighm mutation (56 available)
Igkctm1Bgmn mutation (0 available); any Igkc mutation (9 available)
Igltm2.1Bgmn mutation (0 available); any Igl mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgG level ( J:130864 )
• IgG is not present in the sera
decreased IgM level ( J:130864 )
• IgM is not present in the sera

hematopoietic system
decreased IgG level ( J:130864 )
• IgG is not present in the sera
decreased IgM level ( J:130864 )
• IgM is not present in the sera




Genotype
MGI:3806697
cx3
Allelic
Composition		 Igkctm1Bgmn/Igkctm1Bgmn
Igltm2.1Bgmn/Igltm2.1Bgmn
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkctm1Bgmn mutation (0 available); any Igkc mutation (9 available)
Igltm2.1Bgmn mutation (0 available); any Igl mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:130864 )
• B cell development is partially blocked at the small pre-B cell stage
• cells are released from the bone marrow as B220+CD21/CD35+ B cells
• there is also a small population (0.8%) of B cells expressing Igbeta
abnormal immunoglobulin heavy chain V(D)J recombination ( J:130864 )
• many heavy chain antibodies produced by B cells in these mice lack the Ch1 exon
abnormal plasma cell morphology ( J:130864 )
• plasma cells secrete heavy-chain only IgG
decreased IgG level ( J:130864 )
• reduced but detectable amounts of IgG antibody are found in the sera
• antibodies consist of heavy chain only homodimers
• antigen-specific IgG can be generated by several immunizations of OVA peptide
• these immunizations also result in increases to total IgG levels
decreased IgM level ( J:130864 )
• IgM is not present in the sera

hematopoietic system
abnormal B cell differentiation ( J:130864 )
• B cell development is partially blocked at the small pre-B cell stage
• cells are released from the bone marrow as B220+CD21/CD35+ B cells
• there is also a small population (0.8%) of B cells expressing Igbeta
abnormal immunoglobulin heavy chain V(D)J recombination ( J:130864 )
• many heavy chain antibodies produced by B cells in these mice lack the Ch1 exon
abnormal plasma cell morphology ( J:130864 )
• plasma cells secrete heavy-chain only IgG
decreased IgG level ( J:130864 )
• reduced but detectable amounts of IgG antibody are found in the sera
• antibodies consist of heavy chain only homodimers
• antigen-specific IgG can be generated by several immunizations of OVA peptide
• these immunizations also result in increases to total IgG levels
decreased IgM level ( J:130864 )
• IgM is not present in the sera




Genotype
MGI:3806698
cx4
Allelic
Composition		 Ighmtm3Bgmn/Ighmtm3Bgmn
Igkctm1Bgmn/Igkctm1Bgmn
Igltm2.1Bgmn/Igltm2.1Bgmn
Genetic
Background		 involves: 129P2/OlaHsd * 129/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm3Bgmn mutation (0 available); any Ighm mutation (56 available)
Igkctm1Bgmn mutation (0 available); any Igkc mutation (9 available)
Igltm2.1Bgmn mutation (0 available); any Igl mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:130864 )
• B cell development is partially blocked at the small pre-B cell stage but the expression of a heavy chain-only BCR overcomes this block
• there is a B cell population that makes up 8.4% of splenocytes that express Igbeta
decreased IgG level ( J:130864 )
• reduced but detectable amounts of IgG antibody are found in the sera
• antibodies consist of heavy chain only covalently linked homodimers
decreased IgM level ( J:130864 )
• IgM is present at reduced amounts in the sera
• IgM consist only of heavy chains that are non-covalently linked

immune system
abnormal B cell differentiation ( J:130864 )
• B cell development is partially blocked at the small pre-B cell stage but the expression of a heavy chain-only BCR overcomes this block
• there is a B cell population that makes up 8.4% of splenocytes that express Igbeta
decreased IgG level ( J:130864 )
• reduced but detectable amounts of IgG antibody are found in the sera
• antibodies consist of heavy chain only covalently linked homodimers
decreased IgM level ( J:130864 )
• IgM is present at reduced amounts in the sera
• IgM consist only of heavy chains that are non-covalently linked




Genotype
MGI:3702894
cx5
Allelic
Composition		 Igkctm1Bgmn/Igkctm1Bgmn
Igltm1.1Bgmn/Igltm1.1Bgmn
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkctm1Bgmn mutation (0 available); any Igkc mutation (9 available)
Igltm1.1Bgmn mutation (0 available); any Igl mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal immature B cell morphology ( J:118712 )
• at stage when L chain rearrangement should have been completed, number of IgM+ B220+ cells (0.4 x 106) in bone marrow is reduced by >50% compared to Igk-Ctm1Bgmn mice
decreased B cell number ( J:118712 )
• IgM+ B cells are reduced in number in spleen and secondary lymph organs
absent B-1 B cells ( J:118712 )
• secondary lymphoid organs such as the peritoneum lack B-1 cells
absent B-2 B cells ( J:118712 )
• secondary lymphoid organs such as the peritoneum lack B-2 cells
absent B cells ( J:118712 )
• there is complete lack of mature B cells in spleen
spleen hypoplasia ( J:118712 )
• total cell numbers and weights are reduced by more than half compared to wild-type

immune system
abnormal immature B cell morphology ( J:118712 )
• at stage when L chain rearrangement should have been completed, number of IgM+ B220+ cells (0.4 x 106) in bone marrow is reduced by >50% compared to Igk-Ctm1Bgmn mice
decreased B cell number ( J:118712 )
• IgM+ B cells are reduced in number in spleen and secondary lymph organs
absent B-1 B cells ( J:118712 )
• secondary lymphoid organs such as the peritoneum lack B-1 cells
absent B-2 B cells ( J:118712 )
• secondary lymphoid organs such as the peritoneum lack B-2 cells
absent B cells ( J:118712 )
• there is complete lack of mature B cells in spleen
spleen hypoplasia ( J:118712 )
• total cell numbers and weights are reduced by more than half compared to wild-type




Genotype
MGI:3702900
cx6
Allelic
Composition		 Igkctm1Bgmn/Igkctm1Bgmn
Igltm1Bgmn/Igltm1Bgmn
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkctm1Bgmn mutation (0 available); any Igkc mutation (9 available)
Igltm1Bgmn mutation (0 available); any Igl mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal immature B cell morphology ( J:118712 )
• at stage when L chain rearrangement should have been completed, number of IgM+ B220+ cells (0.4 x 106) in bone marrow is reduced by >50% compared to Igk-Ctm1Bgmn mice
decreased B cell number ( J:118712 )
• IgM+ B cells are reduced in number in spleen and secondary lymph organs
absent mature B cells ( J:118712 )
• there is complete lack of mature B cells in spleen
absent B-1 B cells ( J:118712 )
• secondary lymphoid organs such as the peritoneum lack B-1 cells
absent B-2 B cells ( J:118712 )
• secondary lymphoid organs such as the peritoneum lack B-2 cells
spleen hypoplasia ( J:118712 )
• total cell numbers and weights are reduced by more than half compared to wild-type

immune system
abnormal immature B cell morphology ( J:118712 )
• at stage when L chain rearrangement should have been completed, number of IgM+ B220+ cells (0.4 x 106) in bone marrow is reduced by >50% compared to Igk-Ctm1Bgmn mice
decreased B cell number ( J:118712 )
• IgM+ B cells are reduced in number in spleen and secondary lymph organs
absent mature B cells ( J:118712 )
• there is complete lack of mature B cells in spleen
absent B-1 B cells ( J:118712 )
• secondary lymphoid organs such as the peritoneum lack B-1 cells
absent B-2 B cells ( J:118712 )
• secondary lymphoid organs such as the peritoneum lack B-2 cells
spleen hypoplasia ( J:118712 )
• total cell numbers and weights are reduced by more than half compared to wild-type




Genotype
MGI:3702901
cx7
Allelic
Composition		 Igkctm1Bgmn/Igkctm1Bgmn
Igltm2Bgmn/Igltm2Bgmn
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkctm1Bgmn mutation (0 available); any Igkc mutation (9 available)
Igltm2Bgmn mutation (0 available); any Igl mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:118712 )
• development is blocked at pre-B-II to immature B cell transition stage
absent B cells ( J:118712 )
• IgM+ B cells are undetectable in spleens of mutants

immune system
arrested B cell differentiation ( J:118712 )
• development is blocked at pre-B-II to immature B cell transition stage
absent B cells ( J:118712 )
• IgM+ B cells are undetectable in spleens of mutants




Genotype
MGI:3702904
cx8
Allelic
Composition		 Igkctm1Bgmn/Igkctm1Bgmn
Igltm2.1Bgmn/Igltm2.1Bgmn
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkctm1Bgmn mutation (0 available); any Igkc mutation (9 available)
Igltm2.1Bgmn mutation (0 available); any Igl mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:118712 )
• development is blocked at pre-B-II to immature B cell transition stage
absent B cells ( J:118712 )
• IgM+ B cells are undetectable in spleens of mutants

immune system
arrested B cell differentiation ( J:118712 )
• development is blocked at pre-B-II to immature B cell transition stage
absent B cells ( J:118712 )
• IgM+ B cells are undetectable in spleens of mutants




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory