Phenotypes associated with this allele

• Allele Symbol: Dapp1^{Gt(OST111213)Lex}
• Allele Name: gene trap OST111213, Lexicon Genetics
• Allele ID: MGI:3652582
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dapp1^Gt(OST111213)Lex/Dapp1^Gt(OST111213)Lex	B6.Cg-Dapp1^Gt(OST111213)Lex	MGI:3652749

Genotype
MGI:3652749

hm1

• Allelic Composition: Dapp1^{Gt(OST111213)Lex}/Dapp1^{Gt(OST111213)Lex}
• Genetic Background: B6.Cg-Dapp1^{Gt(OST111213)Lex}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell proliferation ( J:110009 )

• Dapp1-deficient B cell proliferation is reduced by 50% compared to wild-type B cells in response to BCR crosslinking; this decrease is limited to signaling by the BCR since stimulation with other B cell mitogens such as anti-CD40 or LPS results in normal or enhanced mutant B cell proliferation

abnormal humoral immune response ( J:110009 )

• null mice display defective responses to T cell independent type II antigens like TNP-Ficoll; production of IgG3 is markedly reduced

decreased IgG3 level ( J:110009 )

• vaccination of Dapp1-deficient mice with capsular polysaccharide from S. pneumoniae results in production of type 3 polysaccharide-specific IgM antibodies but failure to produce of type 3 polysaccharide-specific IgG3 antibodies

increased susceptibility to bacterial infection ( J:110009 )

• wild-type mice vaccinated with live S. pneumoniae via IP injection show100% survival but all vaccinated Dapp1-deficient die

hematopoietic system

decreased B cell proliferation ( J:110009 )

• Dapp1-deficient B cell proliferation is reduced by 50% compared to wild-type B cells in response to BCR crosslinking; this decrease is limited to signaling by the BCR since stimulation with other B cell mitogens such as anti-CD40 or LPS results in normal or enhanced mutant B cell proliferation

decreased IgG3 level ( J:110009 )

• vaccination of Dapp1-deficient mice with capsular polysaccharide from S. pneumoniae results in production of type 3 polysaccharide-specific IgM antibodies but failure to produce of type 3 polysaccharide-specific IgG3 antibodies

cellular

decreased B cell proliferation ( J:110009 )

• Dapp1-deficient B cell proliferation is reduced by 50% compared to wild-type B cells in response to BCR crosslinking; this decrease is limited to signaling by the BCR since stimulation with other B cell mitogens such as anti-CD40 or LPS results in normal or enhanced mutant B cell proliferation