Phenotypes associated with this allele

• Allele Symbol: Csf2rb2^tm1Cgb
• Allele Name: targeted mutation 1, C Glenn Begley
• Allele ID: MGI:3652583
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Csf2rb2^tm1Cgb/Csf2rb2^tm1Cgb	involves: 129S1/Sv * C57BL/6	MGI:3652888
ht2	Csf2rb2^tm1Cgb/Csf2rb2^+	involves: 129S1/Sv * C57BL/6	MGI:3652887
cx3	Csf2rb^tm1Clsc/Csf2rb^tm1Clsc Csf2rb2^tm1Cgb/Csf2rb2^tm1Cgb	C.129S1-Csf2rb2^tm1Cgb Csf2rb^tm1Clsc	MGI:3839817
cx4	Csf2rb^tm1Clsc/Csf2rb^tm1Clsc Csf2rb2^tm1Cgb/Csf2rb2^tm1Cgb	involves: 129S1/Sv	MGI:3839821

Genotype
MGI:3652888

hm1

• Allelic Composition: Csf2rb2^tm1Cgb/Csf2rb2^tm1Cgb
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal bone marrow cell morphology/development ( J:32978 )

• in culture, progenitor cells are less responsive to stimulation of colony formation by IL3

Genotype
MGI:3652887

ht2

• Allelic Composition: Csf2rb2^tm1Cgb/Csf2rb2⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6

hematopoietic system

abnormal bone marrow cell morphology/development ( J:32978 )

• in culture, progenitor cells show intermediate responsiveness to stimulation of colony formation by IL3, falling between wild-type bone marrow cells and cells from null mice

Genotype
MGI:3839817

cx3

• Allelic Composition: Csf2rb^tm1Clsc/Csf2rb^tm1Clsc; Csf2rb2^tm1Cgb/Csf2rb2^tm1Cgb
• Genetic Background: C.129S1-Csf2rb2^tm1Cgb Csf2rb^tm1Clsc

immune system

impaired eosinophil recruitment ( J:130939 )

• eosinophils fail to migrate to the blood, lung or bronchoalveolar fluid after intranasal challenge with an antigen mice were previously sensitized to

• eosinophil numbers in the peripheral blood, airway lumen, and lung tissue remained at baseline levels for the entire observational period of 2 wk after the final antigen challenge

increased IgG1 level ( J:130939 )

• sera levels of antigen-specific IgG1 are elevated relative to controls in response to challenge with an allergic antigen

abnormal T cell physiology ( J:130939 )

• less CD4⁺ and CD8⁺ T cells are recruited to the lung after allergy challenge than controls

abnormal T cell activation ( J:130939 )

• less peribronchial lymph node T cells are in an activated state after allergy challenge compared to controls

• less activated CD4⁺ T cells are found in the lung after allergy challenge than in controls

decreased T cell proliferation ( J:130939 )

• T cells from allergic mice proliferate less vigorously in response to allergic antigen than controls

lymph node hyperplasia ( J:130939 )

• peribronchial lymph nodes contain about twice as more B cells, CD4⁺ T cells, and CD8⁺ T cells than in controls

• peribronchial lymph nodes also contain more myeloid and plasmacytoid dendritic cells

abnormal dendritic cell physiology ( J:130939 )

• dendritic cells have impaired migration to the lung of both nave and allergy challenged mice compared to respective controls

• myeloid dendritic cells in the lung fail to become activated in response to intranasal allergy challenge

abnormal plasmacytoid dendritic cell physiology ( J:130939 )

• plasmacytoid dendritic cells have impaired migration to the lung of both nave and allergy challenged mice compared to respective controls

decreased susceptibility to type I hypersensitivity reaction ( J:130939 )

• mice fail to increase airway resistance in response to intranasal challenge with an antigen mice were previously sensitized too

• the number of mucus-secreting cells in the lung is half that of wild-type controls after intranasal antigen challenge

• 10-fold less antigen-specific IgE is detected in the sera of mice after antigen challenge

abnormal interleukin secretion ( J:130939 )

decreased interleukin-13 secretion ( J:130939 )

• peribronchial lymph node T cells isolated from allergic mice produce much less IL-13 than controls upon reencounter with allergic antigen

decreased interleukin-4 secretion ( J:130939 )

• peribronchial lymph node T cells isolated from allergic mice produce much less IL-4 than controls upon reencounter with allergic antigen

decreased interleukin-5 secretion ( J:130939 )

• peribronchial lymph node T cells isolated from allergic mice produce much less IL-5 than controls upon reencounter with allergic antigen

respiratory system

decreased airway responsiveness ( J:130939 )

• mice fail to increase airway resistance in response to intranasal antigen challenge

hematopoietic system

impaired eosinophil recruitment ( J:130939 )

• eosinophils fail to migrate to the blood, lung or bronchoalveolar fluid after intranasal challenge with an antigen mice were previously sensitized to

• eosinophil numbers in the peripheral blood, airway lumen, and lung tissue remained at baseline levels for the entire observational period of 2 wk after the final antigen challenge

increased IgG1 level ( J:130939 )

• sera levels of antigen-specific IgG1 are elevated relative to controls in response to challenge with an allergic antigen

abnormal T cell physiology ( J:130939 )

• less CD4⁺ and CD8⁺ T cells are recruited to the lung after allergy challenge than controls

abnormal T cell activation ( J:130939 )

• less peribronchial lymph node T cells are in an activated state after allergy challenge compared to controls

• less activated CD4⁺ T cells are found in the lung after allergy challenge than in controls

decreased T cell proliferation ( J:130939 )

• T cells from allergic mice proliferate less vigorously in response to allergic antigen than controls

cellular

decreased T cell proliferation ( J:130939 )

• T cells from allergic mice proliferate less vigorously in response to allergic antigen than controls

Genotype
MGI:3839821

cx4

• Allelic Composition: Csf2rb^tm1Clsc/Csf2rb^tm1Clsc; Csf2rb2^tm1Cgb/Csf2rb2^tm1Cgb
• Genetic Background: involves: 129S1/Sv

hematopoietic system

abnormal bone marrow cell number ( J:109889 )

• bone marrow cells from mice 6-14 weeks of age do not proliferate when exposed to cytokines like Il-3 or GM-CSF but response to other cytokines is normal