About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fli1tm1Ber
targeted mutation 1, Alan Bernstein
MGI:3652588
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fli1tm1Ber/Fli1tm1Ber either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1) MGI:3652765
hm2
 		Fli1tm1Ber/Fli1tm1Ber involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 MGI:3652766
ht3
 		Fli1tm1Ber/Fli1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 MGI:3652768


Genotype
MGI:3652765
hm1
Allelic
Composition		 Fli1tm1Ber/Fli1tm1Ber
Genetic
Background		 either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fli1tm1Ber mutation (0 available); any Fli1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased thymocyte number ( J:33052 )
• thymocyte numbers are decreased by 30-50% compared to control mice

immune system
decreased thymocyte number ( J:33052 )
• thymocyte numbers are decreased by 30-50% compared to control mice

endocrine/exocrine glands
decreased thymocyte number ( J:33052 )
• thymocyte numbers are decreased by 30-50% compared to control mice




Genotype
MGI:3652766
hm2
Allelic
Composition		 Fli1tm1Ber/Fli1tm1Ber
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fli1tm1Ber mutation (0 available); any Fli1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged spleen ( J:33052 )
• mice develop splenomegaly a characteristic of Friend leukemia

hematopoietic system
enlarged spleen ( J:33052 )
• mice develop splenomegaly a characteristic of Friend leukemia
anemia ( J:33052 )
• mice develop severe anemia leading to lethality characteristic of Friend leukemia
decreased hematocrit ( J:33052 )
• infected null mice show decreased hematocrits around day 55 while in wild-type, hematocrits start to drop around day 40

neoplasm
increased leukemia incidence ( J:33052 )
• null mice for Fli1 from matings of heterozygous animals infected with F-MuLV at birth develop but the disease has a consistently longer latency period than littermate controls

growth/size/body
enlarged spleen ( J:33052 )
• mice develop splenomegaly a characteristic of Friend leukemia




Genotype
MGI:3652768
ht3
Allelic
Composition		 Fli1tm1Ber/Fli1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fli1tm1Ber mutation (0 available); any Fli1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased leukemia incidence ( J:33052 )
• latency period falls between infected homozygous animals and that of infected wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory