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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fli1tm1Ber
targeted mutation 1, Alan Bernstein
MGI:3652588
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fli1tm1Ber/Fli1tm1Ber either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1) MGI:3652765
hm2
 		Fli1tm1Ber/Fli1tm1Ber involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 MGI:3652766
ht3
 		Fli1tm1Ber/Fli1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 MGI:3652768


Genotype
MGI:3652765
hm1
Allelic
Composition		 Fli1tm1Ber/Fli1tm1Ber
Genetic
Background		 either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fli1tm1Ber mutation (0 available); any Fli1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased thymocyte number ( J:33052 )
• thymocyte numbers are decreased by 30-50% compared to control mice

immune system
decreased thymocyte number ( J:33052 )
• thymocyte numbers are decreased by 30-50% compared to control mice

endocrine/exocrine glands
decreased thymocyte number ( J:33052 )
• thymocyte numbers are decreased by 30-50% compared to control mice




Genotype
MGI:3652766
hm2
Allelic
Composition		 Fli1tm1Ber/Fli1tm1Ber
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fli1tm1Ber mutation (0 available); any Fli1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged spleen ( J:33052 )
• mice develop splenomegaly a characteristic of Friend leukemia

hematopoietic system
enlarged spleen ( J:33052 )
• mice develop splenomegaly a characteristic of Friend leukemia
anemia ( J:33052 )
• mice develop severe anemia leading to lethality characteristic of Friend leukemia
decreased hematocrit ( J:33052 )
• infected null mice show decreased hematocrits around day 55 while in wild-type, hematocrits start to drop around day 40

neoplasm
increased leukemia incidence ( J:33052 )
• null mice for Fli1 from matings of heterozygous animals infected with F-MuLV at birth develop but the disease has a consistently longer latency period than littermate controls

growth/size/body
enlarged spleen ( J:33052 )
• mice develop splenomegaly a characteristic of Friend leukemia




Genotype
MGI:3652768
ht3
Allelic
Composition		 Fli1tm1Ber/Fli1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fli1tm1Ber mutation (0 available); any Fli1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased leukemia incidence ( J:33052 )
• latency period falls between infected homozygous animals and that of infected wild-type




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory