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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gba/Mtx1tm1Bst
targeted mutation 1, Paul Bornstein
MGI:3652597
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Gba1tm1Bst/Gba1tm1Bst
Gba/Mtx1tm1Bst/Gba/Mtx1tm1Bst
involves: 129S4/SvJae MGI:3652807
cx2
Gba1tm1Bst/Gba1tm1Nsb
Gba/Mtx1tm1Bst/Mtx1+
involves: 129S/SvEv * 129S4/SvJae MGI:3652806


Genotype
MGI:3652807
cx1
Allelic
Composition
Gba1tm1Bst/Gba1tm1Bst
Gba/Mtx1tm1Bst/Gba/Mtx1tm1Bst
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gba1tm1Bst mutation (0 available); any Gba1 mutation (47 available)
Gba/Mtx1tm1Bst mutation (0 available); any Mtx1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• examination of pregnant mice at 9 days post conception revealed multiple sites of resorption among the developing embryos; homozygous embryos die between day 4 and 9




Genotype
MGI:3652806
cx2
Allelic
Composition
Gba1tm1Bst/Gba1tm1Nsb
Gba/Mtx1tm1Bst/Mtx1+
Genetic
Background
involves: 129S/SvEv * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gba1tm1Bst mutation (0 available); any Gba1 mutation (47 available)
Gba1tm1Nsb mutation (2 available); any Gba1 mutation (47 available)
Gba/Mtx1tm1Bst mutation (0 available); any Mtx1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• animals die within 24 hours of birth

homeostasis/metabolism
• mutants have about 5% of control glucocerebrosidase activity





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory