All Phenotypes Gnai3<tm1Lbi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gnai3^tm1Lbi
targeted mutation 1, Lutz Birnbaumer
MGI:3652743

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gnai3^tm1Lbi/Gnai3^tm1Lbi	B6.129S-Gnai3^tm1Lbi	MGI:3710684
hm2	Gnai3^tm1Lbi/Gnai3^tm1Lbi	involves: 129S/SvEv	MGI:5471654
hm3	Gnai3^tm1Lbi/Gnai3^tm1Lbi	involves: 129S/SvEv * C57BL/6	MGI:3710147
cn4	Gnai2^tm2.1Lbi/Gnai2^tm2.1Lbi Gnai3^tm1Lbi/Gnai3^tm1Lbi Sox9^tm3(cre)Crm/Sox9⁺	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6	MGI:5471658
cn5	Gnai2^tm2.1Lbi/Gnai2⁺ Gnai3^tm1Lbi/Gnai3^tm1Lbi Sox9^tm3(cre)Crm/Sox9⁺	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6	MGI:5471659
cn6	Gnai2^tm2.1Lbi/Gnai2^tm2.1Lbi Gnai3^tm1Lbi/Gnai3^tm1Lbi Tg(Myog-cre)1Eno/0	involves: 129S/SvEv * C57BL/6	MGI:5471660
cx7	Gnai1^tm1Drs/Gnai1^tm1Drs Gnai3^tm1Lbi/Gnai3^tm1Lbi	involves: 129S/SvEv	MGI:3710144
cx8	Gnai1^tm1Drs/Gnai1⁺ Gnai3^tm1Lbi/Gnai3^tm1Lbi	involves: 129S/SvEv	MGI:5471655
cx9	Gnai2^tm1Lbi/Gnai2⁺ Gnai3^tm1Lbi/Gnai3^tm1Lbi	involves: 129S/SvEv * 129S7/SvEvBrd	MGI:5471656

Allelic Composition	Gnai3^tm1Lbi/Gnai3^tm1Lbi
Genetic Background	B6.129S-Gnai3^tm1Lbi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai3^tm1Lbi mutation (1 available); any Gnai3 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell physiology ( J:121161 )

• activated T cells show dramatically increased response to CXCL9 and CXCL11, and a lesser increased response to CXCL10 in vitro, relative to wild-type cells; GTPgammaS membrane incorporation is significantly increased in response to CXCR3 agonist stimulation, correlating with enhanced chemotaxis

• CXCL12-evoked chemotactic responses are diminished compared to wild-type controls

hematopoietic system

abnormal T cell physiology ( J:121161 )

• CXCL12-evoked chemotactic responses are diminished compared to wild-type controls

Allelic Composition	Gnai3^tm1Lbi/Gnai3^tm1Lbi
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai3^tm1Lbi mutation (1 available); any Gnai3 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Fusion of lumbar vertebrae in Gnai3^tm1Lbi/Gnai3^tm1Lbi mice

skeleton

abnormal sternocostal joint morphology ( J:193170 )

• one mouse has the eighth rib ectopically attached to the sternum

abnormal rib morphology ( J:193170 )

• a single mouse lacking rib fusions had small triangular outgrowths of cartilage at the distal end of the second rib pair

rib fusion ( J:193170 )

• Background Sensitivity: fusions of the cartilaginous portion of the distal ribs are seen in 95% of mice on a 129S/SvEv background but in less than 40% of mice on a mixed 129S/SvEv and C57BL/6 background

• Background Sensitivity: the average number of fusions is reduced in mice on a mixed 129S/SvEv and C57BL/6 background compared to mice on a 129S/SvEv background

• fusions typically involve only ribs that articulate with the sternum

• ectopic connection of the eighth rib to the sternum is seen in 1 case

• fusions are detected as early as E14.5

abnormal lumbar vertebrae morphology ( J:193170 )

• Background Sensitivity: incidence of lumbar defects in reduced in mice on a mixed 129S/SvEv and C57BL/6 background compared to mice on a 129S/SvEv background

• deformation or partial fusion of one or more vertebral bodies in 9 of 10 mice in the lumbar region

• in 2 of 10 pups pointed outgrowths that do not fuse are detected

lumbar vertebral fusion ( J:193170 )

• in 7 of 10 pups a small bridge of bone connecting the bodies of two or three adjacent vertebrae is present

Allelic Composition	Gnai3^tm1Lbi/Gnai3^tm1Lbi
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai3^tm1Lbi mutation (1 available); any Gnai3 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Fusion of lumbar vertebrae in Gnai3^tm1Lbi/Gnai3^tm1Lbi mice

skeleton

rib fusion ( J:193170 )

• Background Sensitivity: the average number of fusions is reduced in mice on a mixed 129S/SvEv and C57BL/6 background compared to mice on a 129S/SvEv background

abnormal lumbar vertebrae morphology ( J:193170 )

• Background Sensitivity: incidence of lumbar defects in reduced in mice on a mixed 129S/SvEv and C57BL/6 background compared to mice on a 129S/SvEv background

immune system

immune system phenotype ( J:120069 )

N	• OVA-induced tissue accumulation of eosinophils is normal

Allelic Composition	Gnai2^tm2.1Lbi/Gnai2^tm2.1Lbi Gnai3^tm1Lbi/Gnai3^tm1Lbi Sox9^tm3(cre)Crm/Sox9⁺
Genetic Background	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai2^tm2.1Lbi mutation (0 available); any Gnai2 mutation (56 available)
Gnai3^tm1Lbi mutation (1 available); any Gnai3 mutation (28 available)
Sox9^tm3(cre)Crm mutation (1 available); any Sox9 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Rib fusion phenotype is enhanced in Gnai3^tm1Lbi/Gnai3^tm1Lbi mice by loss of Gnai2 in cartilage

skeleton

rib fusion ( J:193170 )

• rib fusions are more severe compared to mice homozygous for Gnai3^tm1Lbi alone

lumbar vertebral fusion ( J:193170 )

• not noticeably more severe than in mice homozygous for Gnai3^tm1Lbi alone

Allelic Composition	Gnai2^tm2.1Lbi/Gnai2⁺ Gnai3^tm1Lbi/Gnai3^tm1Lbi Sox9^tm3(cre)Crm/Sox9⁺
Genetic Background	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

rib fusion ( J:193170 )

• rib fusions are more severe compared to mice homozygous for Gnai3^tm1Lbi alone

Allelic Composition	Gnai2^tm2.1Lbi/Gnai2^tm2.1Lbi Gnai3^tm1Lbi/Gnai3^tm1Lbi Tg(Myog-cre)1Eno/0
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Rib fusion phenotype is enhanced in Gnai3^tm1Lbi/Gnai3^tm1Lbi mice by loss of Gnai2 in cartilage

skeleton

rib fusion ( J:193170 )

• rib fusions are similar in severity to mice homozygous for Gnai3^tm1Lbi alone

Allelic Composition	Gnai1^tm1Drs/Gnai1^tm1Drs Gnai3^tm1Lbi/Gnai3^tm1Lbi
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai1^tm1Drs mutation (0 available); any Gnai1 mutation (15 available)
Gnai3^tm1Lbi mutation (1 available); any Gnai3 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Rib and sternum defects in mice with mutations of Gnai1, Gnai2, and/or Gnai3

immune system

decreased interleukin-10 secretion ( J:104683 )

• decrease in IL-10 production from peritoneal monocytes after in vitro lipopolysaccharide-induction

increased tumor necrosis factor secretion ( J:104683 )

• increase in TNFa production from spleen monocytes after in vitro lipopolysaccharide-induction

homeostasis/metabolism

abnormal thromboxane level ( J:104683 )

• decreased thromboxane production B2 from peritoneal monocytes after in vitro lipopolysaccharide-induction

skeleton

sternebra fusion ( J:193170 )

asymmetric sternocostal joints ( J:193170 )

rib fusion ( J:193170 )

• rib fusions are more frequent and severe compared to mice homozygous for Gnai3^tm1Lbi alone

• rib fusions frequently involve both true and false ribs

lumbar vertebral fusion ( J:193170 )

• not noticeably more severe than in ice homozygous for Gnai3^tm1Lbi alone

Allelic Composition	Gnai1^tm1Drs/Gnai1⁺ Gnai3^tm1Lbi/Gnai3^tm1Lbi
Genetic Background	involves: 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Rib and sternum defects in mice with mutations of Gnai1, Gnai2, and/or Gnai3

skeleton

sternebra fusion ( J:193170 )

rib fusion ( J:193170 )

• rib fusions are more frequent and severe compared to mice homozygous for Gnai3^tm1Lbi alone

• rib fusions frequently involve both true and false ribs

lumbar vertebral fusion ( J:193170 )

• not noticeably more severe than in mice homozygous for Gnai3^tm1Lbi alone

Allelic Composition	Gnai2^tm1Lbi/Gnai2⁺ Gnai3^tm1Lbi/Gnai3^tm1Lbi
Genetic Background	involves: 129S/SvEv * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai2^tm1Lbi mutation (1 available); any Gnai2 mutation (56 available)
Gnai3^tm1Lbi mutation (1 available); any Gnai3 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Rib and sternum defects in mice with mutations of Gnai1, Gnai2, and/or Gnai3

skeleton

abnormal sternocostal joint morphology ( J:193170 )

• one mouse has the eighth rib ectopically attached to the sternum

rib fusion ( J:193170 )

• rib fusions are similar in severity to mice homozygous for Gnai3^tm1Lbi and Gnai1^tm1Drs

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