All Phenotypes Ren1<tm1Tkh> MGI Mouse

postnatal lethality, incomplete penetrance ( J:110082 )

• about 80% die before weaning; however the lifespan of survivors is similar to wild-type

• injection of saline from P1 to 2 weeks of age rescues lethality in about 50% of mice

abnormal kidney afferent arteriole morphology ( J:110082 )

• the wall of afferent arterioles is thickened and contains more cells

abnormal kidney interlobular artery morphology ( J:110082 )

• the wall of interlobular arteries is thickened and contains more cells

abnormal urine homeostasis ( J:110082 )

• daily urinary excretion of aldosterone is less than 10% of wild-type mice

decreased urine osmolality ( J:110082 )

• following 12 hours of water deprivation mice fail to concentrate their urine

• treatment with 1 ng/g desmopressin fails to increase urine osmolality unlike in wild-type mice

kidney inflammation ( J:110082 )

• perivascular infiltration of mononuclear cells

glomerulosclerosis ( J:110082 )

• focal

renal interstitial fibrosis ( J:110082 )

kidney papillary atrophy ( J:110082 )

• severely affected kidneys may display papillary atrophy

kidney papillary hypoplasia ( J:110082 )

• severely affected kidneys display atrophic or hypoplastic papilla

hydronephrosis ( J:110082 )

• variable severity hydronephrosis develops after birth

• severely affected kidneys have a dilated renal pelvis

small kidney ( J:110082 )

kidney medulla atrophy ( J:110082 )

• severely affected kidneys have a thinned medulla

granular kidney ( J:110082 )

• surface of severely affected kidneys appears granular

polyuria ( J:110082 )

• excrete about 5 times more urine daily; however daily urinary sodium, potassium, chloride and creatinine excretion are similar to wild-type

abnormal kidney afferent arteriole morphology ( J:110082 )

• the wall of afferent arterioles is thickened and contains more cells

abnormal kidney interlobular artery morphology ( J:110082 )

• the wall of interlobular arteries is thickened and contains more cells

decreased systemic arterial blood pressure ( J:110082 )

• at 4 months of age blood pressure is about 30 mmHg lower than wild-type mice

• treatment with Angiotensin II restores blood pressure to normal

increased circulating creatinine level ( J:110082 )

• at 4 months of age

increased blood urea nitrogen level ( J:110082 )

• at 4 months of age

decreased circulating angiotensin II level ( J:110082 )

• angiotensin II is undetectable in plasma

decreased circulating renin level ( J:110082 )

• renin and angiotensins I and II are undetectable in plasma

dehydration ( J:110082 )

• during 12 hours of water deprivation mice lose over 20% of their body weight

metabolic acidosis ( J:110082 )

• metabolic acidosis at 4 months of age