Phenotypes associated with this allele

• Allele Symbol: Inhbc^tm1Zuk
• Allele Name: targeted mutation 1, Martin M Matzuk
• Allele ID: MGI:3653269
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Inhbc^tm1Zuk/Inhbc^tm1Zuk	either: (involves: 129S5/SvEvBrd * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)	MGI:3653332
cx2	Inhbc^tm1Zuk/Inhbc^tm1Zuk Inhbe^tm1Zuk/Inhbe^tm1Zuk	either: (involves: 129S5/SvEvBrd * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)	MGI:3653333

Genotype
MGI:3653332

hm1

• Allelic Composition: Inhbc^tm1Zuk/Inhbc^tm1Zuk
• Genetic Background: either: (involves: 129S5/SvEvBrd * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating serum albumin level ( J:110815 )

• females but not males display a significant decrease in serum albumin levels compared to wild-type mice

liver/biliary system

liver/biliary system phenotype ( J:110815 )

N • liver morphology, histology and function, liver mass to body mass ratio, response to partial hepatectomy, and body weight are all normal

reproductive system

reproductive system phenotype ( J:110815 )

N • serum FSH levels in males, gonad morphology and histology, and fertility are all normal

Genotype
MGI:3653333

cx2

• Allelic Composition: Inhbc^tm1Zuk/Inhbc^tm1Zuk; Inhbe^tm1Zuk/Inhbe^tm1Zuk
• Genetic Background: either: (involves: 129S5/SvEvBrd * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

normal phenotype

no abnormal phenotype detected ( J:110815 )

• body weight, liver morphology, histology and function, liver mass to body mass ratio, response to partial hepatectomy, serum FSH levels in males, serum albumin levels, gonad morphology and histology, and fertility are all normal