Phenotypes associated with this allele

• Allele Symbol: Igh^tm4Cog
• Allele Name: targeted mutation 4, Michel Cogne
• Allele ID: MGI:3653375
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh^tm4Cog/Igh^tm4Cog	involves: 129S2/SvPas * C57BL/6	MGI:3653884
ht2	Igh^tm4Cog/Igh^+	involves: 129S2/SvPas * C57BL/6	MGI:3653885

Genotype
MGI:3653884

hm1

• Allelic Composition: Igh^tm4Cog/Igh^tm4Cog
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

small spleen ( J:109988 )

• homozygous animals have spleens of reduced size

absent spleen germinal center ( J:109988 )

absent Peyer's patches ( J:109988 )

• Peyer's patches are absent

hematopoietic system

small spleen ( J:109988 )

• homozygous animals have spleens of reduced size

absent spleen germinal center ( J:109988 )

Genotype
MGI:3653885

ht2

• Allelic Composition: Igh^tm4Cog/Igh⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

immune system

increased IgA level ( J:109988 )

• a low but significant level of IgA^a is detected in the serum of heterozygotes but is absent in C57BL/6 controls and abundant in BALB/c controls

• IgA^a producing plasmocytes are present in heterozygotes but are absent in C57BL/6 controls and abundant in BALB/c controls

decreased IgM level ( J:109988 )

• heterozygotes do not express IgM^a

hematopoietic system

increased IgA level ( J:109988 )

• a low but significant level of IgA^a is detected in the serum of heterozygotes but is absent in C57BL/6 controls and abundant in BALB/c controls

• IgA^a producing plasmocytes are present in heterozygotes but are absent in C57BL/6 controls and abundant in BALB/c controls

decreased IgM level ( J:109988 )

• heterozygotes do not express IgM^a