mortality/aging
• embryos die between day E9.5 and E10.5
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cardiovascular system
• embryos exhibit a bulged pericardial cavity at E9-9.5
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nervous system
• failure of neural tube closure is observed at E9.9.5
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• E9-9.5 homozygous embryos display a wavy neural tube
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embryo
• failure of neural tube closure is observed at E9.9.5
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• E9-9.5 homozygous embryos display a wavy neural tube
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