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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ptentm1.1Hwu
targeted mutation 1.1, Hong Wu
MGI:3653378
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ptentm1.1Hwu/Ptentm1.1Hwu involves: 129S4/SvJae * BALB/c MGI:3707138
ht2
Ptentm1.1Hwu/Pten+ involves: 129S4/SvJae * BALB/c MGI:3707122
ht3
Ptentm1.1Hwu/Pten+ involves: 129S4/SvJae * BALB/c * C57BL/6 MGI:3707123
ht4
Ptentm1.1Hwu/Pten+ involves: 129S4/SvJae * C57BL/6NTac MGI:5008590
cx5
Ptentm1.1Hwu/Pten+
Tmprss2tm1.1(ERG)Sho/Tmprss2tm1.1(ERG)Sho
involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:5578646
cx6
Ptentm1.1Hwu/Pten+
Tmprss2tm2.1(ETV1)Sho/Tmprss2tm2.1(ETV1)Sho
involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:5578648
cx7
Del(16Tmprss2-Erg)1Sho/Del(16Tmprss2-Erg)1Sho
Ptentm1.1Hwu/Pten+
involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:5578651
cx8
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+
Ptentm1.1Hwu/Pten+
involves: 129S4/SvJae * C57BL/6NTac MGI:5008591


Genotype
MGI:3707138
hm1
Allelic
Composition
Ptentm1.1Hwu/Ptentm1.1Hwu
Genetic
Background
involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1.1Hwu mutation (0 available); any Pten mutation (88 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos die between day E9.5 and E10.5

cardiovascular system
• embryos exhibit a bulged pericardial cavity at E9-9.5

nervous system
• failure of neural tube closure is observed at E9.9.5
• E9-9.5 homozygous embryos display a wavy neural tube

embryo
• failure of neural tube closure is observed at E9.9.5
• E9-9.5 homozygous embryos display a wavy neural tube




Genotype
MGI:3707122
ht2
Allelic
Composition
Ptentm1.1Hwu/Pten+
Genetic
Background
involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1.1Hwu mutation (0 available); any Pten mutation (88 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• most of the tumor seen are benign and isolated, but in three cases malignant transformation was observed; in two mice, local invasion occurred while in one, whole body metastasis occurred
• onset of tumor formation on the BALB/c background is delayed compared to that reported on other backgrounds; 90% of heterozygotes are tumor-free for their first 6 months, and only 50% have developed tumors by 10 months of age
• Background Sensitivity: 9% of aged 7-14 month old females show endometrial hyperplasia on this background
• 30% of females develop mammary tumors ranging from 1-10 tumors per animal
• 95% of male mice aged 10-15 months display prostate abnormalities ranging from hyperplasia to local invasion
• 45% of female uteri have hemangioma lesions at 7-14 months; these masses consist of aggregates of endothelium-lined blood filled spaces of variable sizes
• in some areas, tissue resembled arterioles or venules, while at edges of large spaces, there are small capillary aggregates; smaller vessels are packed with erythrocytes
• vascular abnormalities are also found in the brain, mammary glands, spinal cord or body walls of some heterozygotes, but at lower frequencies than in the uterus

cardiovascular system
• similar lesions to those in the uterus are occasionally observed in the brain of some mice at 14 months
• in a male at 14 months, the lesions of the cerebrum and olfactory bulb were aggregates of endothelium-lined, cavernous blood-filled spaces separated by narrow connective-tissue septa; blood in some spaces was thrombosed and calcified
• aggregates of capillary arteriole- and venule-like vessels similar to the ones in the uteri are observed

reproductive system
• 95% of male mice aged 10-15 months display prostate abnormalities ranging from hyperplasia to local invasion
• hemangiomas are predominantly in the myometrium, involve the whole uterine wall, and protrude into the uterine lumen

immune system
• incidence of lymphoid hyperplasia or neoplasia is 25%

nervous system
• similar lesions to those in the uterus are occasionally observed in the brain of some mice at 14 months
• in a male at 14 months, the lesions of the cerebrum and olfactory bulb were aggregates of endothelium-lined, cavernous blood-filled spaces separated by narrow connective-tissue septa; blood in some spaces was thrombosed and calcified
• aggregates of capillary arteriole- and venule-like vessels similar to the ones in the uteri are observed
• in a male at 14 months, the left olfactory bulb and frontal lobes of the cerebrum seem to be replaced by masses of hemorrhagic-appearing tissue; the mouse seemed ataxic, with enlargement of the forehead

integument
• 30% of females develop mammary tumors ranging from 1-10 tumors per animal

endocrine/exocrine glands
• 30% of females develop mammary tumors ranging from 1-10 tumors per animal
• 95% of male mice aged 10-15 months display prostate abnormalities ranging from hyperplasia to local invasion




Genotype
MGI:3707123
ht3
Allelic
Composition
Ptentm1.1Hwu/Pten+
Genetic
Background
involves: 129S4/SvJae * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1.1Hwu mutation (0 available); any Pten mutation (88 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• Background Sensitivity: 25% of aged 7-14 month old F2 females show endometrial hyperplasia compared to 9% on 129/BALB/c background




Genotype
MGI:5008590
ht4
Allelic
Composition
Ptentm1.1Hwu/Pten+
Genetic
Background
involves: 129S4/SvJae * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1.1Hwu mutation (0 available); any Pten mutation (88 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• at 6 to 7 months of age

endocrine/exocrine glands




Genotype
MGI:5578646
cx5
Allelic
Composition
Ptentm1.1Hwu/Pten+
Tmprss2tm1.1(ERG)Sho/Tmprss2tm1.1(ERG)Sho
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1.1Hwu mutation (0 available); any Pten mutation (88 available)
Tmprss2tm1.1(ERG)Sho mutation (0 available); any Tmprss2 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:5578648
cx6
Allelic
Composition
Ptentm1.1Hwu/Pten+
Tmprss2tm2.1(ETV1)Sho/Tmprss2tm2.1(ETV1)Sho
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1.1Hwu mutation (0 available); any Pten mutation (88 available)
Tmprss2tm2.1(ETV1)Sho mutation (0 available); any Tmprss2 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:5578651
cx7
Allelic
Composition
Del(16Tmprss2-Erg)1Sho/Del(16Tmprss2-Erg)1Sho
Ptentm1.1Hwu/Pten+
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(16Tmprss2-Erg)1Sho mutation (0 available); any Del(16Tmprss2-Erg)1Sho mutation (0 available)
Ptentm1.1Hwu mutation (0 available); any Pten mutation (88 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:5008591
cx8
Allelic
Composition
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+
Ptentm1.1Hwu/Pten+
Genetic
Background
involves: 129S4/SvJae * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Ptentm1.1Hwu mutation (0 available); any Pten mutation (88 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• in doxycycline-treated mice
• at 6 to 7 months of age in doxycycline-treated mice

endocrine/exocrine glands
• in doxycycline-treated mice





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory