Phenotypes associated with this allele

• Allele Symbol: Prokr1^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3653379
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prokr1^tm1Lex/Prokr1^tm1Lex	involves: 129S/SvEvBrd * C57BL/6J	MGI:3653508

Genotype
MGI:3653508

hm1

• Allelic Composition: Prokr1^tm1Lex/Prokr1^tm1Lex
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased body temperature ( J:109984 )

behavior/neurological

abnormal fluid intake ( J:109984 )

• addition of capsaicin to sweetened drinking water resulted in increased water consumption in mutants but reduced consumption in wild-type; only at concentrations greater than 30 umol did mutants decrease their consumption of the treated water

abnormal nociception after inflammation ( J:109984 )

• after application of mustard oil solution to the hindpaws, thermal hyperalgesia in response to a 48 degree hot plate is induced within 15 minutes in wild-type but produces a slight thermal threshold decrease that recovers in 60 minutes in mutants

• inflammation of one paw does not affect weight bearing behavior in mutants but causes wild-type mice to bear less weight on the inflamed paw

hypoalgesia ( J:109984 )

• i.p. injection of dilute acetic acid produces less intense and shorter-lasting writhing episodes in mutant mice

• capsaicin injection in the hind paw produced significantly reduced responses in mutants compared to wild-type

hyporesponsive to tactile stimuli ( J:109984 )

• plantar injection of Bv8 causes wild-type mice to bear more weight on the contralateral paw, but does not affect weight-bearing in mutants

increased chemical nociceptive threshold ( J:109984 )

• intraplantar injections of capsaicin alone or capsaicin after 50 fmol of Bv8 do not induce licking as they do in wild-type

abnormal thermal nociception ( J:109984 )

• subcutaneous and plantar injection of Bv8 in wild-type produces intense and long-lasting sensitization to thermal stimuli, but does not change the threshold in mutants; a dose 20x that used in wild-type is necessary to see the same effect in mutants

• intrapaw injection of capsaicin does not induce thermal hyperalgesia as is does in wild-type, but injection of bradykinin produced similar effects in mutants and wild-type

increased thermal nociceptive threshold ( J:109984 )

• at temperatures lower than 50 degrees Celsius, the latency for response is 1.5-2.3-fold longer than for wild-type in the hot-plate test; at 51 degrees, latencies were comparable to wild-type

• when hot water is applied to the tail, at temperatures of 43-48 degrees, withdrawal latencies are 1.5 to 2-fold longer for Prokr-null mice compared to wild-type