All Phenotypes Gcm1<tm1Hoso> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gcm1^tm1Hoso
targeted mutation 1, Toshihiko Hosoya
MGI:3653426

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gcm1^tm1Hoso/Gcm1^tm1Hoso	either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * CD-1)	MGI:3662929
cx2	Gcm1^tm1Hoso/Gcm1^tm1Hoso Gcm2^tm1Hoso/Gcm2^tm1Hoso	either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * CD-1)	MGI:5292472

Allelic Composition	Gcm1^tm1Hoso/Gcm1^tm1Hoso
Genetic Background	either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * CD-1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcm1^tm1Hoso mutation (0 available); any Gcm1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:175891 )

• between E9.5 and E10.5

nervous system

abnormal neuron differentiation ( J:175891 )

• neural stem cell induction is impaired

cellular

abnormal neuron differentiation ( J:175891 )

• neural stem cell induction is impaired

Allelic Composition	Gcm1^tm1Hoso/Gcm1^tm1Hoso Gcm2^tm1Hoso/Gcm2^tm1Hoso
Genetic Background	either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * CD-1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcm1^tm1Hoso mutation (0 available); any Gcm1 mutation (23 available)
Gcm2^tm1Hoso mutation (0 available); any Gcm2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:175891 )

nervous system

abnormal neuron differentiation ( J:175891 )

• neural stem cell induction is impaired

cellular

abnormal neuron differentiation ( J:175891 )

• neural stem cell induction is impaired

abnormal DNA methylation ( J:175891 )

• at E8.33, demethylation of the Hes5 promoter is impaired

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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