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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Htr2atm1Grch
targeted mutation 1, Jay A Gingrich
MGI:3653429
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Htr2atm1Grch/Htr2atm1Grch 129S6/SvEvTac-Htr2atm1Grch MGI:3663439
hm2
 		Htr2atm1Grch/Htr2atm1Grch involves: 129S6/SvEvTac MGI:3837409
ht3
 		Htr2atm1Grch/Htr2atm2Grch 129S6/SvEv-Htr2atm1Grch Htr2atm2Grch MGI:3663440
ht4
 		Htr2atm1Grch/Htr2atm2Grch involves: 129S6/SvEvTac MGI:3663443
cn5
 		Emx1tm1(cre)Ito/Emx1+
Htr2atm1Grch/Htr2atm2Grch 		129S6.Cg-Htr2atm1Grch Htr2atm2Grch Emx1tm1(cre)Ito MGI:3663441
cn6
 		Htr2atm1Grch/Htr2atm2Grch
Slc6a4tm1(cre)Grch/Slc6a4+ 		involves: 129S6/SvEvTac MGI:3663444


Genotype
MGI:3663439
hm1
Allelic
Composition		 Htr2atm1Grch/Htr2atm1Grch
Genetic
Background		 129S6/SvEvTac-Htr2atm1Grch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2atm1Grch mutation (0 available); any Htr2a mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal anxiety-related response ( J:110958 )
• reduced inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors
• home cage activity did not differ
• motor coordination, strength, and sensory processing were unimpaired
• baseline concentrations and the rise in corticosterone release following anxiety tests were comparable
• cell number, mantel thickness, barrel field formation, or the expression of GABA containing neuronal markers are normal
decreased anxiety-related response ( J:110958 )
• explored the lit compartment to a greater extent in the dark-light choice test
• explored the riskier portions of the elevated plus-maze to a greater extent
• exhibited a shorter latency to begin feeding in a novel environment
increased vertical activity ( J:110958 )
• in open field




Genotype
MGI:3837409
hm2
Allelic
Composition		 Htr2atm1Grch/Htr2atm1Grch
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2atm1Grch mutation (0 available); any Htr2a mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:146078 )
N
• despite being expressed in osteoblasts, no skeletal abnormalities are detected at 1 or 3 months of age




Genotype
MGI:3663440
ht3
Allelic
Composition		 Htr2atm1Grch/Htr2atm2Grch
Genetic
Background		 129S6/SvEv-Htr2atm1Grch Htr2atm2Grch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2atm1Grch mutation (0 available); any Htr2a mutation (43 available)
Htr2atm2Grch mutation (0 available); any Htr2a mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal anxiety-related response ( J:110958 )
• reduced inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors
• home cage activity did not differ
• motor coordination, strength, and sensory processing were unimpaired
• baseline concentrations and the rise in corticosterone release following anxiety tests were comparable
• cell number, mantel thickness, barrel field formation, or the expression of GABA containing neuronal markers are normal
decreased anxiety-related response ( J:110958 )
• explored the lit compartment to a greater extent in the dark-light choice test
• explored the riskier portions of the elevated plus-maze to a greater extent
• exhibited a shorter latency to begin feeding in a novel environment
increased vertical activity ( J:110958 )
• in open field




Genotype
MGI:3663443
ht4
Allelic
Composition		 Htr2atm1Grch/Htr2atm2Grch
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2atm1Grch mutation (0 available); any Htr2a mutation (43 available)
Htr2atm2Grch mutation (0 available); any Htr2a mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal anxiety-related response ( J:110958 )
• reduced inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors in the dark-light choice test




Genotype
MGI:3663441
cn5
Allelic
Composition		 Emx1tm1(cre)Ito/Emx1+
Htr2atm1Grch/Htr2atm2Grch
Genetic
Background		 129S6.Cg-Htr2atm1Grch Htr2atm2Grch Emx1tm1(cre)Ito
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Ito mutation (1 available); any Emx1 mutation (34 available)
Htr2atm1Grch mutation (0 available); any Htr2a mutation (43 available)
Htr2atm2Grch mutation (0 available); any Htr2a mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:110958 )
N
• selective restoration of 5HT2AR signaling to the cortex normalized conflict anxiety behaviors
• exhibited wild-type levels of anxiety-like behavior as measured by the open field test, dark-light choice test, and novelty suppressed feeding paradigm
• depression-related paradigms, such as the forced swim test and tail suspension test, were unchanged compared to un-restored homozygous null litter mate




Genotype
MGI:3663444
cn6
Allelic
Composition		 Htr2atm1Grch/Htr2atm2Grch
Slc6a4tm1(cre)Grch/Slc6a4+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2atm1Grch mutation (0 available); any Htr2a mutation (43 available)
Htr2atm2Grch mutation (0 available); any Htr2a mutation (43 available)
Slc6a4tm1(cre)Grch mutation (0 available); any Slc6a4 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal anxiety-related response ( J:110958 )
• reduced inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors in the dark-light choice test
• selective restoration of 5HT2AR signaling to the thalamus did not normalized conflict anxiety behaviors




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory