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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Igk-V4CH27)1-2Shc
transgene insertion 1-2, Stephen H Clarke
MGI:3653438
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Ightm1Kplm/Ightm4Cgn
Tg(Igk-V4CH27)1-2Shc/0 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:3693009
cx2
 		Igll1tm1Cgn/Igll1tm1Cgn
Tg(Igk-V4CH27)1-2Shc/0 		involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL MGI:3689734
cx3
 		Ightm1Kplm/Igh+
Tg(Igk-V4CH27)1-2Shc/0 		involves: C57BL/6 * SJL MGI:3693010


Genotype
MGI:3693009
cx1
Allelic
Composition		 Ightm1Kplm/Ightm4Cgn
Tg(Igk-V4CH27)1-2Shc/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1Kplm mutation (0 available); any Igh mutation (44 available)
Ightm4Cgn mutation (0 available); any Igh mutation (44 available)
Tg(Igk-V4CH27)1-2Shc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased B cell number ( J:115292 )
• splenic B cell number is increased 3- to 5-fold compared to Tg(Igk-V4CH27)1-2Shc or Ightm4Cgn, Tg(Igk-V4CH27)1-2Shc mutants

immune system
increased B cell number ( J:115292 )
• splenic B cell number is increased 3- to 5-fold compared to Tg(Igk-V4CH27)1-2Shc or Ightm4Cgn, Tg(Igk-V4CH27)1-2Shc mutants




Genotype
MGI:3689734
cx2
Allelic
Composition		 Igll1tm1Cgn/Igll1tm1Cgn
Tg(Igk-V4CH27)1-2Shc/0
Genetic
Background		 involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igll1tm1Cgn mutation (1 available); any Igll1 mutation (16 available)
Tg(Igk-V4CH27)1-2Shc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:35357 )
• more than 80% of CD43+ B cell progenitors express the transgene in the cytoplasm, compared to only 22% of wild-type cells at a similar developmental stage which express a kappa chain
decreased pre-B cell number ( J:35357 )
• about a 3- to 4-fold reduction in pre-B cells; however, the overall numbers of immature and mature B cell numbers are similar to wild-type

hematopoietic system
abnormal B cell differentiation ( J:35357 )
• more than 80% of CD43+ B cell progenitors express the transgene in the cytoplasm, compared to only 22% of wild-type cells at a similar developmental stage which express a kappa chain
decreased pre-B cell number ( J:35357 )
• about a 3- to 4-fold reduction in pre-B cells; however, the overall numbers of immature and mature B cell numbers are similar to wild-type




Genotype
MGI:3693010
cx3
Allelic
Composition		 Ightm1Kplm/Igh+
Tg(Igk-V4CH27)1-2Shc/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1Kplm mutation (0 available); any Igh mutation (44 available)
Tg(Igk-V4CH27)1-2Shc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased B cell number ( J:115292 )
• mice have 2-fold more splenic B cells than Ightm1Kplm mutants and 8-fold more cells than Tg(Igk-V4CH27)1-2Shc or Ightm4Cgn, Tg(Igk-V4CH27)1-2Shc mutants

immune system
increased B cell number ( J:115292 )
• mice have 2-fold more splenic B cells than Ightm1Kplm mutants and 8-fold more cells than Tg(Igk-V4CH27)1-2Shc or Ightm4Cgn, Tg(Igk-V4CH27)1-2Shc mutants




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory