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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Suz12tm1Hko
targeted mutation 1, Haruhiko Koseki
MGI:3653454
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Suz12tm1Hko/Suz12tm1Hko Not Specified MGI:3703524
ht2
Suz12tm1Hko/Suz12+ Not Specified MGI:4946504
cx3
Mtf2tm1.1Hko/Mtf2tm1.1Hko
Suz12tm1Hko/Suz12+
involves: C57BL/6 MGI:4946505


Genotype
MGI:3703524
hm1
Allelic
Composition
Suz12tm1Hko/Suz12tm1Hko
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suz12tm1Hko mutation (0 available); any Suz12 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• phenotype is stated to be almost identical to that of Suz12Gt(Betageo)1Khe but no data is shown in J:109525

embryo

growth/size/body




Genotype
MGI:4946504
ht2
Allelic
Composition
Suz12tm1Hko/Suz12+
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suz12tm1Hko mutation (0 available); any Suz12 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• mice exhibit homeotic transformation of the axis compared with wild-type mice
• 57% of mice exhibit T13 to L1 transformation
• 7% of mice exhibit C5 to C6 transformation
• 18% of mice exhibit C6 to T1 transformation
• 76% of mice exhibit L6 to S1 transformation




Genotype
MGI:4946505
cx3
Allelic
Composition
Mtf2tm1.1Hko/Mtf2tm1.1Hko
Suz12tm1Hko/Suz12+
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtf2tm1.1Hko mutation (0 available); any Mtf2 mutation (314 available)
Suz12tm1Hko mutation (0 available); any Suz12 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• shifted anteriorly
• perfect ribs are associated with C7
• homeotic transformation is enhanced compared to in Mtf2tm1.1Hko homozygotes
• unlike in wild-type mice, a prominent spinous process is associated with T1 instead of T2
• 75% of mice exhibit T1 to T2 transformation
• 75% of mice exhibit T13 to L1 transformation
• unlike in wild-type mice, anterior tuberculums are associated with C5 instead of C6 and perfect ribs are associated with C7
• 25% of mice exhibit C1 to C2 transforamtion
• 42% of mice exhibit C2 to C3 transformation
• 42% of mice exhibit C5 to C6 transformation
• 58% of mice exhibit C6 to T1 transformation
• 92% of mice exhibit L6 to S1 transformation





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory