All Phenotypes Suz12<tm1Hko> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Suz12^tm1Hko
targeted mutation 1, Haruhiko Koseki
MGI:3653454

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Suz12^tm1Hko/Suz12^tm1Hko	Not Specified	MGI:3703524
ht2	Suz12^tm1Hko/Suz12⁺	Not Specified	MGI:4946504
cx3	Mtf2^tm1.1Hko/Mtf2^tm1.1Hko Suz12^tm1Hko/Suz12⁺	involves: C57BL/6	MGI:4946505

Allelic Composition	Suz12^tm1Hko/Suz12^tm1Hko
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suz12^tm1Hko mutation (0 available); any Suz12 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:109525 )

• phenotype is stated to be almost identical to that of Suz12^{Gt(Betageo)1Khe} but no data is shown in J:109525

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:170279 )

• mice died around E8.5

embryo

decreased embryo size ( J:109525 )

abnormal extraembryonic tissue morphology ( J:109525 )

growth/size/body

decreased embryo size ( J:109525 )

Allelic Composition	Suz12^tm1Hko/Suz12⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suz12^tm1Hko mutation (0 available); any Suz12 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

vertebral transformation ( J:170279 )

• mice exhibit homeotic transformation of the axis compared with wild-type mice

thoracic vertebral transformation ( J:170279 )

• 57% of mice exhibit T13 to L1 transformation

cervical vertebral transformation ( J:170279 )

• 7% of mice exhibit C5 to C6 transformation

• 18% of mice exhibit C6 to T1 transformation

lumbar vertebral transformation ( J:170279 )

• 76% of mice exhibit L6 to S1 transformation

Allelic Composition	Mtf2^tm1.1Hko/Mtf2^tm1.1Hko Suz12^tm1Hko/Suz12⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtf2^tm1.1Hko mutation (0 available); any Mtf2 mutation (314 available)
Suz12^tm1Hko mutation (0 available); any Suz12 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal sternum morphology ( J:170279 )

• shifted anteriorly

increased rib number ( J:170279 )

• perfect ribs are associated with C7

vertebral transformation ( J:170279 )

• homeotic transformation is enhanced compared to in Mtf2^tm1.1Hko homozygotes

thoracic vertebral transformation ( J:170279 )

• unlike in wild-type mice, a prominent spinous process is associated with T1 instead of T2

• 75% of mice exhibit T1 to T2 transformation

• 75% of mice exhibit T13 to L1 transformation

cervical vertebral transformation ( J:170279 )

• unlike in wild-type mice, anterior tuberculums are associated with C5 instead of C6 and perfect ribs are associated with C7

• 25% of mice exhibit C1 to C2 transforamtion

• 42% of mice exhibit C2 to C3 transformation

• 42% of mice exhibit C5 to C6 transformation

• 58% of mice exhibit C6 to T1 transformation

lumbar vertebral transformation ( J:170279 )

• 92% of mice exhibit L6 to S1 transformation

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