Phenotypes associated with this allele

• Allele Symbol: Rr163^tm1Lfdn
• Allele Name: targeted mutation 1, Laurent Ferradini
• Allele ID: MGI:3653474
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr163^tm1Lfdn/Rr163^tm1Lfdn	either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CB20)	MGI:3713395
ht2	Rr163^tm1Lfdn/Rr163^+	either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CB20)	MGI:3713396

Genotype
MGI:3713395

hm1

• Allelic Composition: Rr163^tm1Lfdn/Rr163^tm1Lfdn
• Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CB20)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:31727 )

N • 2-3 week-old mice have peripheral B cell in normal numbers with unmodified kappa/lamda ratios

N • bone marrow cells show normal proportions of pro-B, pre-B, and immature B cells in 4-6 week-old mice

abnormal immune system physiology ( J:31727 )

• in mutants, a significant decrease (~80%) in immunoglobulin gene V_kappa- J_kappa rearrangement

Genotype
MGI:3713396

ht2

• Allelic Composition: Rr163^tm1Lfdn/Rr163⁺
• Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CB20)

immune system

immune system phenotype ( J:31727 )

N • 2-3 week-old mice have peripheral B cell in normal numbers with unmodified kappa/lamda ratios

N • bone marrow cells show normal proportions of pro-B, pre-B, and immature B cells in 4-6 week-old mice

abnormal immune system physiology ( J:31727 )

• in mutants, a significant decrease (~80%) in immunoglobulin gene V_kappa- J_kappa rearrangement