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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd80tm1Lbgn
targeted mutation 1, Laurence Bugeon
MGI:3653492
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd80tm1Lbgn/Cd80tm1Lbgn C3.Cg-Cd80tm1Lbgn MGI:3663051


Genotype
MGI:3663051
hm1
Allelic
Composition		 Cd80tm1Lbgn/Cd80tm1Lbgn
Genetic
Background		 C3.Cg-Cd80tm1Lbgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd80tm1Lbgn mutation (0 available); any Cd80 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell physiology ( J:110947 )
• homozygous mutant mice did not delete T cells bearing mammary tumor virus-reactive TCR as efficiently as wild-type animals
• they had normal percentage of CD4+, CD8+, B220+ and CD3+ cells in spleen, LN, thymus, payers patches and bone marrow

hematopoietic system
abnormal T cell physiology ( J:110947 )
• homozygous mutant mice did not delete T cells bearing mammary tumor virus-reactive TCR as efficiently as wild-type animals
• they had normal percentage of CD4+, CD8+, B220+ and CD3+ cells in spleen, LN, thymus, payers patches and bone marrow




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory