About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd80tm1Lbgn
targeted mutation 1, Laurence Bugeon
MGI:3653492
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd80tm1Lbgn/Cd80tm1Lbgn C3.Cg-Cd80tm1Lbgn MGI:3663051


Genotype
MGI:3663051
hm1
Allelic
Composition		 Cd80tm1Lbgn/Cd80tm1Lbgn
Genetic
Background		 C3.Cg-Cd80tm1Lbgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd80tm1Lbgn mutation (0 available); any Cd80 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell physiology ( J:110947 )
• homozygous mutant mice did not delete T cells bearing mammary tumor virus-reactive TCR as efficiently as wild-type animals
• they had normal percentage of CD4+, CD8+, B220+ and CD3+ cells in spleen, LN, thymus, payers patches and bone marrow

hematopoietic system
abnormal T cell physiology ( J:110947 )
• homozygous mutant mice did not delete T cells bearing mammary tumor virus-reactive TCR as efficiently as wild-type animals
• they had normal percentage of CD4+, CD8+, B220+ and CD3+ cells in spleen, LN, thymus, payers patches and bone marrow




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory