All Phenotypes Nisch<edsn> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nisch^edsn/Nisch^edsn	C3H.B6-Nisch^edsn	MGI:6101180
ht2	Nisch^edsn/Nisch^V33A	involves: BALB/c * C3H/HeH * C57BL/6J	MGI:6101184
cx3	Itga5^tm1Hyn/Itga5⁺ Nisch^edsn/Nisch^edsn	C3H.Cg-Nisch^edsn Itga5^tm1Hyn	MGI:6101182
cx4	Itga5^tm1Hyn/Itga5⁺ Nisch^edsn/Nisch⁺	C3H.Cg-Nisch^edsn Itga5^tm1Hyn	MGI:6101183

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:244907 )

• likely due to lung defects

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:244907 )

N	• no obvious abnormalities observed in the cochlea with no hair cell damage or loss

abnormal middle ear ossicle morphology ( J:244907 )

• cavity is filled with cellular exudate and thickened mucoperiosteum due to inflammation

abnormal tympanic membrane morphology ( J:244907 )

• inflammed

increased or absent threshold for auditory brainstem response ( J:244907 )

• at 3 weeks and progressively worsening with age

impaired hearing ( J:244907 )

increased susceptibility to otitis media ( J:244907 )

• from 3 weeks onward beginning as unilateral and progressing to bilateral at 20 weeks in some mice

• inflamed mucoperiosteum and tympanic membrane, increased mucosal thickness, increased macrophage infiltration, and exudate with enlarged foamy macrophages containing coarsely granular material

respiratory system

abnormal lung-associated mesenchyme development ( J:244907 )

• thickened with smaller airspaces at E16.5, E18.5 and P0 in some mice

emphysema ( J:244907 )

• enlarged airspaces with accumulation of enlarged alveolar macrophage containing coarsely granular material in adult mice

• severity corresponds to severity of otitis media

growth/size/body

short snout ( J:244907 )

decreased body size ( J:244907 )

• at 20 weeks in female and male mice

decreased body weight ( J:244907 )

• at 20 weeks in female and male mice

postnatal growth retardation ( J:244907 )

craniofacial

abnormal middle ear ossicle morphology ( J:244907 )

• cavity is filled with cellular exudate and thickened mucoperiosteum due to inflammation

short snout ( J:244907 )

immune system

increased susceptibility to otitis media ( J:244907 )

• from 3 weeks onward beginning as unilateral and progressing to bilateral at 20 weeks in some mice

• inflamed mucoperiosteum and tympanic membrane, increased mucosal thickness, increased macrophage infiltration, and exudate with enlarged foamy macrophages containing coarsely granular material

skeleton

abnormal middle ear ossicle morphology ( J:244907 )

• cavity is filled with cellular exudate and thickened mucoperiosteum due to inflammation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
otitis media		DOID:10754		J:244907

Allelic Composition	Nisch^edsn/Nisch^V33A
Genetic Background	involves: BALB/c * C3H/HeH * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nisch^edsn mutation (0 available); any Nisch mutation (73 available)
Nisch^V33A mutation (0 available); any Nisch mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:244907 )

• onset at 4 weeks, progressive

increased susceptibility to otitis media ( J:244907 )

• onset at 4 weeks, progressive

• increased intermediate middle ear mucosal thickness

immune system

increased susceptibility to otitis media ( J:244907 )

• onset at 4 weeks, progressive

• increased intermediate middle ear mucosal thickness

Allelic Composition	Itga5^tm1Hyn/Itga5⁺ Nisch^edsn/Nisch^edsn
Genetic Background	C3H.Cg-Nisch^edsn Itga5^tm1Hyn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga5^tm1Hyn mutation (1 available); any Itga5 mutation (47 available)
Nisch^edsn mutation (0 available); any Nisch mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:244907 )

• more so than in Nisch^edsn homozygotes at 4 and 20 weeks

impaired hearing ( J:244907 )

• at 4 weeks

increased susceptibility to otitis media ( J:244907 )

• more so than in Nisch^edsn homozygotes at 4 and 20 weeks

• cavity is filled with cellular exudate and thickened mucoperiosteum due to inflammation

immune system

increased susceptibility to otitis media ( J:244907 )

• more so than in Nisch^edsn homozygotes at 4 and 20 weeks

• cavity is filled with cellular exudate and thickened mucoperiosteum due to inflammation

Allelic Composition	Itga5^tm1Hyn/Itga5⁺ Nisch^edsn/Nisch⁺
Genetic Background	C3H.Cg-Nisch^edsn Itga5^tm1Hyn

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

impaired hearing ( J:244907 )

• mild with onset at 12 weeks unlike single heterozygotes

increased susceptibility to otitis media ( J:244907 )

• from 12 weeks with muscosal thickening unlike single heterozygotes

immune system

increased susceptibility to otitis media ( J:244907 )

• from 12 weeks with muscosal thickening unlike single heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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