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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nischedsn
edison
MGI:3653501
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nischedsn/Nischedsn C3H.B6-Nischedsn MGI:6101180
ht2
 		Nischedsn/NischV33A involves: BALB/c * C3H/HeH * C57BL/6J MGI:6101184
cx3
 		Itga5tm1Hyn/Itga5+
Nischedsn/Nischedsn 		C3H.Cg-Nischedsn Itga5tm1Hyn MGI:6101182
cx4
 		Itga5tm1Hyn/Itga5+
Nischedsn/Nisch+ 		C3H.Cg-Nischedsn Itga5tm1Hyn MGI:6101183


Genotype
MGI:6101180
hm1
Allelic
Composition		 Nischedsn/Nischedsn
Genetic
Background		 C3H.B6-Nischedsn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nischedsn mutation (0 available); any Nisch mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:244907 )
• likely due to lung defects

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:244907 )
N
• no obvious abnormalities observed in the cochlea with no hair cell damage or loss
abnormal middle ear ossicle morphology ( J:244907 )
• cavity is filled with cellular exudate and thickened mucoperiosteum due to inflammation
increased or absent threshold for auditory brainstem response ( J:244907 )
• at 3 weeks and progressively worsening with age
increased susceptibility to otitis media ( J:244907 )
• from 3 weeks onward beginning as unilateral and progressing to bilateral at 20 weeks in some mice
• inflamed mucoperiosteum and tympanic membrane, increased mucosal thickness, increased macrophage infiltration, and exudate with enlarged foamy macrophages containing coarsely granular material

respiratory system
abnormal lung-associated mesenchyme development ( J:244907 )
• thickened with smaller airspaces at E16.5, E18.5 and P0 in some mice
emphysema ( J:244907 )
• enlarged airspaces with accumulation of enlarged alveolar macrophage containing coarsely granular material in adult mice
• severity corresponds to severity of otitis media

growth/size/body
short snout ( J:244907 )
decreased body size ( J:244907 )
• at 20 weeks in female and male mice
decreased body weight ( J:244907 )
• at 20 weeks in female and male mice
postnatal growth retardation ( J:244907 )

craniofacial
abnormal middle ear ossicle morphology ( J:244907 )
• cavity is filled with cellular exudate and thickened mucoperiosteum due to inflammation

immune system
increased susceptibility to otitis media ( J:244907 )
• from 3 weeks onward beginning as unilateral and progressing to bilateral at 20 weeks in some mice
• inflamed mucoperiosteum and tympanic membrane, increased mucosal thickness, increased macrophage infiltration, and exudate with enlarged foamy macrophages containing coarsely granular material

skeleton
abnormal middle ear ossicle morphology ( J:244907 )
• cavity is filled with cellular exudate and thickened mucoperiosteum due to inflammation

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
otitis media DOID:10754 J:244907




Genotype
MGI:6101184
ht2
Allelic
Composition		 Nischedsn/NischV33A
Genetic
Background		 involves: BALB/c * C3H/HeH * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nischedsn mutation (0 available); any Nisch mutation (72 available)
NischV33A mutation (0 available); any Nisch mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
increased susceptibility to otitis media ( J:244907 )
• onset at 4 weeks, progressive
• increased intermediate middle ear mucosal thickness

immune system
increased susceptibility to otitis media ( J:244907 )
• onset at 4 weeks, progressive
• increased intermediate middle ear mucosal thickness




Genotype
MGI:6101182
cx3
Allelic
Composition		 Itga5tm1Hyn/Itga5+
Nischedsn/Nischedsn
Genetic
Background		 C3H.Cg-Nischedsn Itga5tm1Hyn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga5tm1Hyn mutation (1 available); any Itga5 mutation (45 available)
Nischedsn mutation (0 available); any Nisch mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
increased or absent threshold for auditory brainstem response ( J:244907 )
• more so than in Nischedsn homozygotes at 4 and 20 weeks
impaired hearing ( J:244907 )
• at 4 weeks
increased susceptibility to otitis media ( J:244907 )
• more so than in Nischedsn homozygotes at 4 and 20 weeks
• cavity is filled with cellular exudate and thickened mucoperiosteum due to inflammation

immune system
increased susceptibility to otitis media ( J:244907 )
• more so than in Nischedsn homozygotes at 4 and 20 weeks
• cavity is filled with cellular exudate and thickened mucoperiosteum due to inflammation




Genotype
MGI:6101183
cx4
Allelic
Composition		 Itga5tm1Hyn/Itga5+
Nischedsn/Nisch+
Genetic
Background		 C3H.Cg-Nischedsn Itga5tm1Hyn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga5tm1Hyn mutation (1 available); any Itga5 mutation (45 available)
Nischedsn mutation (0 available); any Nisch mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
impaired hearing ( J:244907 )
• mild with onset at 12 weeks unlike single heterozygotes
increased susceptibility to otitis media ( J:244907 )
• from 12 weeks with muscosal thickening unlike single heterozygotes

immune system
increased susceptibility to otitis media ( J:244907 )
• from 12 weeks with muscosal thickening unlike single heterozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory