Phenotypes associated with this allele

• Allele Symbol: Zfp423^tm1.2Ngc
• Allele Name: targeted mutation 1.2, Neal G Copeland
• Allele ID: MGI:3653506
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp423^tm1.2Ngc/Zfp423^tm1.2Ngc	involves: 129S1/Sv * C57BL/6 * CD-1	MGI:3653605
ht2	Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1	MGI:3653607

Genotype
MGI:3653605

hm1

• Allelic Composition: Zfp423^tm1.2Ngc/Zfp423^tm1.2Ngc
• Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality at weaning, incomplete penetrance ( J:111316 )

• significant numbers die before or right around weaning

premature death ( J:111316 )

• survival beyond 1 year only with special care

behavior/neurological

abnormal food intake ( J:111316 )

• require wet food placed on the bottom of the cage

abnormal motor coordination/balance ( J:111316 )

ataxia ( J:111316 )

• starting before 2 weeks of age

abnormal gait ( J:111316 )

• wobbling

nervous system

decreased hindbrain size ( J:111316 )

• particularly reduced in size

decreased brain size ( J:111316 )

• brain structures from the diencephalons to the myelencephalon are hypomorphic by birth

abnormal cerebellum morphology ( J:111316 )

• hemispheres are greatly reduced

reduced cerebellar foliation ( J:111316 )

• greatly reduced

abnormal Purkinje cell dendrite morphology ( J:111316 )

• reduced dendritic formation

• dendritic arbor eventually forms but is simplified

ectopic Purkinje cell ( J:111316 )

• some purkinje cells are ectopic

abnormal cerebellum vermis morphology ( J:111316 )

• severely reduced in size

growth/size/body

decreased body size ( J:111316 )

homeostasis/metabolism

dehydration ( J:111316 )

• occasional saline injections may be required to prevent dehydration

Genotype
MGI:3653607

ht2

• Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1

nervous system

reduced cerebellar foliation ( J:111316 )

• reduced foliation and normal Purkinje cell localization

small cerebellum ( J:111316 )

• reduced in size