Phenotypes associated with this allele

• Allele Symbol: Als2^tm1Hay
• Allele Name: targeted mutation 1, M R Hayden
• Allele ID: MGI:3653518
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Als2^tm1Hay/Als2^tm1Hay	involves: 129S1/SvImJ * C57BL/6J	MGI:3653642

Genotype
MGI:3653642

hm1

• Allelic Composition: Als2^tm1Hay/Als2^tm1Hay
• Genetic Background: involves: 129S1/SvImJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased locomotor activity ( J:111035 )

• at 15 months of age, open-field activity tests reveal that homozygotes are hypoactive; this is true for 3 month old mice as well and did not worsen with age

nervous system

abnormal neuron morphology ( J:111035 )

• measures of neuronal size reveal that mutant neurons have smaller cell bodies and axons of diminished caliber but these did not reach significance except in the motor cortex

• receptor trafficking is disturbed in homozygotes; ability to support Rab5-dependent endosome fusion is impaired

• in culture, neurons show abnormal endosomal receptor (TrkB and IGF1R) trafficking

abnormal motor neuron morphology ( J:111035 )

• upper motorneurons in layer V of the motor cortex have significantly smaller cell bodies (7% reduction in mean cell area) at 12 months of age compared to controls;