endocrine/exocrine glands
• thyroids have a disordered follicle architecture more noticeable with age compared to control Titf1tm2Shk homozygotes
• cultured follicular cells form irregular-shaped polygonal structures lacking colloid accumulation compared to mature, spherical colloid-containing follicles formed by cells from Titf1tm2Shk homozygotes
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homeostasis/metabolism
• mean serum TSH levels are higher than in Titf1tm2Shk homozygous mice but statistical significance was not obtained
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