All Phenotypes Tg(tetO-CDK5R1/GFP)337Lht MGI Mouse

decreased body weight ( J:104240 )

• transgenic mice with transgene expression induced by removal of doxycycline from their food 4-6 weeks postnatal exhibit a slightly decreased body weight compared to control littermates

amyloid beta deposits ( J:177847 )

• mice with transgene expression induced by removal of doxycycline from the food 4-6 weeks postnatal exhibit amyloid beta deposits in the hippocampus

decreased brain weight ( J:104240 , J:177847 )

• transgenic mice with induction of expression of the transgene for different time periods display progressive decrease in brain weight; with induction for 5 weeks there is a 15-20% decrease in brain weight and with more than 12 weeks of induction, the weight decrease is 30% (J:104240)

abnormal forebrain morphology ( J:104240 )

• in transgenic mice induced for 8 and 12 weeks, there is an increase in aggregations of tau protein (insoluble tau) with an increased amount of phosphorylated tau present; at 15 weeks, there is less soluble tau than in wild-type forebrains and similar results are found at 27 weeks of induction

abnormal hippocampus morphology ( J:104240 )

• brains of transgenic mice induced for 12 weeks show a significant decrease in thickness and neuronal density in the hippocampus compared to controls

hippocampal neuron degeneration ( J:177847 )

• 50% reduction in the number of NeuN-positive cells in hippocampal area CA1 in 6-week induced mice

thin cerebral cortex ( J:104240 )

• brains of transgenic mice induced for 12 weeks show a significant decrease in thickness and neuronal density in the cerebral cortex compared to controls; mice induced for 8 or 12 weeks show a 25 or 40% decrease in cortical neuronal density, respectively, whereas wild-type or non-induced transgenic mice had the same neuronal density

forebrain atrophy ( J:104240 )

• induced transgenic mice at 12 weeks postnatal display significant forebrain atrophy with decrease in forebrain mass

neurofibrillary tangles ( J:104240 )

• neurofibrillary tangle-like pathology is exhibited in brains of transgenic mice induced for 27 weeks; there are numerous intraneuronal and flame-shaped neurons positive for neurofibrillary tangle-specific proteins in the cortex and hippocampus of transgenic mice but not wild-type

• other methosds also identify neurofibrillary tangle-like structures in the cerebral cortex, hippocampus and entorhinal cortex of transgenic mice

• brains of transgenic mice induced for 8 or 12 weeks do not express markers for late stage tangles similar to what is observed in wild-type

gliosis ( J:104240 )

• reactive astrogliosis is increased throughout the cortex and hippocampus of mutants evident by an increase in radial and stellate-shaped astrocytes

astrocytosis ( J:177847 )

• reactive astrogliosis is seen in the cortex and hippocampus in 6-week induced mice

abnormal synapse morphology ( J:177847 )

• mice exhibit reduced density of synaptophysin puncta in the stratum radiatum of the hippocampus, indicating reduced synapse density following a 6-week induction

impaired synaptic plasticity ( J:177847 )

• mice exhibit impaired synaptic plasticity following a 6-week induction

reduced long-term potentiation ( J:177847 )

• mice exhibit diminished CA1 long term potentiation (LTP) following a 6-week induction

impaired contextual conditioning behavior ( J:177847 )

• associative learning in contextual fear conditioning is impaired in 6-week induced mice, with mice spending less time freezing after training than wild-type mice

amyloid beta deposits ( J:177847 )

• mice with transgene expression induced by removal of doxycycline from the food 4-6 weeks postnatal exhibit amyloid beta deposits in the hippocampus

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:177847

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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