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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ighdtm1Lam
targeted mutation 1, Marinus C Lamers
MGI:3653691
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ighdtm1Lam/Ighdtm1Lam involves: 129S2/SvPas * C57BL/6 MGI:3653763
ht2
 		Ighdtm1Lam/Ighd+ involves: 129S2/SvPas * C57BL/6 MGI:3653764


Genotype
MGI:3653763
hm1
Allelic
Composition		 Ighdtm1Lam/Ighdtm1Lam
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighdtm1Lam mutation (0 available); any Ighd mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukopoiesis ( J:111020 )
• homozygous mice show a reduction of 50-70% in splenocyte and lymph node cell numbers compared to wild-type
abnormal B cell physiology ( J:111020 )
• mutants show slightly lower responses to thymus dependent antigen such as DNP-ovalbumin
increased IgA level ( J:111020 )
• mutants have 2-fold higher IgA than wild-type
decreased IgG2b level ( J:111020 )
• mice have 4.5-fold lower IgG2b levels than wild-type

hematopoietic system
abnormal leukopoiesis ( J:111020 )
• homozygous mice show a reduction of 50-70% in splenocyte and lymph node cell numbers compared to wild-type
abnormal B cell physiology ( J:111020 )
• mutants show slightly lower responses to thymus dependent antigen such as DNP-ovalbumin
increased IgA level ( J:111020 )
• mutants have 2-fold higher IgA than wild-type
decreased IgG2b level ( J:111020 )
• mice have 4.5-fold lower IgG2b levels than wild-type




Genotype
MGI:3653764
ht2
Allelic
Composition		 Ighdtm1Lam/Ighd+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighdtm1Lam mutation (0 available); any Ighd mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:111020 )
• heterozygotes have ~ 50% fewer B cells of the Iga allotype in the spleen and lymph nodes

immune system
decreased B cell number ( J:111020 )
• heterozygotes have ~ 50% fewer B cells of the Iga allotype in the spleen and lymph nodes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory