Phenotypes associated with this allele

• Allele Symbol: Msh6^tm1Wed
• Allele Name: targeted mutation 1, Winfried Edelmann
• Allele ID: MGI:3653701
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Msh6^tm1Wed/Msh6^tm1Wed	involves: 129/Sv * C57BL/6J * SJL	MGI:3654142
ht2	Msh6^tm1Wed/Msh6^+	involves: 129/Sv * C57BL/6J * SJL	MGI:3654144

Genotype
MGI:3654142

hm1

• Allelic Composition: Msh6^tm1Wed/Msh6^tm1Wed
• Genetic Background: involves: 129/Sv * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

increased intestinal adenoma incidence ( J:92555 )

• tumors are found in the small intestines of mice including tubular adenomas (2/12), a tubovillous adenoma (1/12) and focal areas of dysplasia (4/12)

mortality/aging

decreased tumor-free survival time ( J:92555 )

• 50% survival of homozygotes is 12 months and all mice die by 20 months of age from tumors

neoplasm

increased tumor incidence ( J:92555 )

• homozygous mutants show increased susceptibility to tumor development

increased intestinal adenoma incidence ( J:92555 )

• tumors are found in the small intestines of mice including tubular adenomas (2/12), a tubovillous adenoma (1/12) and focal areas of dysplasia (4/12)

increased basal cell carcinoma incidence ( J:92555 )

• some mice develop basal cell carcinomas of the skin (2/12)

increased lymphoma incidence ( J:92555 )

• majority of mice develop B or T cell non-Hodgkins lymphomas (11/12)

integument

increased basal cell carcinoma incidence ( J:92555 )

• some mice develop basal cell carcinomas of the skin (2/12)

Genotype
MGI:3654144

ht2

• Allelic Composition: Msh6^tm1Wed/Msh6⁺
• Genetic Background: involves: 129/Sv * C57BL/6J * SJL

neoplasm

increased lymphoma incidence ( J:92555 )

• 7/11 heterozygotes sacrificed between 17 and 22 months of age had developed non-Hodgkins lymphoma compared to 0 wild-type