Phenotypes associated with this allele

• Allele Symbol: Gadd45g^tm1Mhol
• Allele Name: targeted mutation 1, M Christine Hollander
• Allele ID: MGI:3653832
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gadd45g^tm1Mhol/Gadd45g^tm1Mhol	involves: 129	MGI:3653938
hm2	Gadd45g^tm1Mhol/Gadd45g^tm1Mhol	involves: C57BL/6N	MGI:5461350
cx3	Gadd45a^tm1Ajf/Gadd45a^tm1Ajf Gadd45b^tm1Daa/Gadd45b^tm1Daa Gadd45g^tm1Mhol/Gadd45g^tm1Mhol	either: (involves: 129X1/SvJ) or (involves: 129P2/OlaHsd * 129X1/SvJ)	MGI:3653937

Genotype
MGI:3653938

hm1

• Allelic Composition: Gadd45g^tm1Mhol/Gadd45g^tm1Mhol
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:110650 )

• confluent 2nd passage renal medullary cells show reduced viability in when stressed by NaCl or urea at 1240 mosmol/kg water compared to wild-type cells

Genotype
MGI:5461350

hm2

• Allelic Composition: Gadd45g^tm1Mhol/Gadd45g^tm1Mhol
• Genetic Background: involves: C57BL/6N

reproductive system

abnormal testis development ( J:191095 )

• at E14.5 XY gonads are smaller compared to wild-type controls

• expression analysis indicates early male gonad specification is permanently interrupted in XY gonads

absent testis cords ( J:191095 )

• at E14.5 XY gonads lack testis cords

primary sex reversal ( J:191095 )

• male to female sex reversal with internal reproductive organs in XY mice closely resembling those in XX mice

• ovaries and uteri are comparable in size and shape in XY and XX mice

• only 3.5% of homozygous mice are phenotypically male but the expected percentage of XY mice are found

secondary sex reversal ( J:191095 )

• male to female sex reversal with external genitalia in XY mice closely resembling those in XX mice

infertility ( J:191095 )

• XY females are infertile; however, XX females are fertile

endocrine/exocrine glands

abnormal testis development ( J:191095 )

• at E14.5 XY gonads are smaller compared to wild-type controls

• expression analysis indicates early male gonad specification is permanently interrupted in XY gonads

absent testis cords ( J:191095 )

• at E14.5 XY gonads lack testis cords

Genotype
MGI:3653937

cx3

• Allelic Composition: Gadd45a^tm1Ajf/Gadd45a^tm1Ajf; Gadd45b^tm1Daa/Gadd45b^tm1Daa; Gadd45g^tm1Mhol/Gadd45g^tm1Mhol
• Genetic Background: either: (involves: 129X1/SvJ) or (involves: 129P2/OlaHsd * 129X1/SvJ)

cellular

increased cell proliferation ( J:110650 )

• proliferation in the outer medullas of triple knockouts