Analysis Tools
immune system
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• eosinophils fail to migrate to the blood, lung or bronchoalveolar fluid after intranasal challenge with an antigen mice were previously sensitized to
• eosinophil numbers in the peripheral blood, airway lumen, and lung tissue remained at baseline levels for the entire observational period of 2 wk after the final antigen challenge
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• sera levels of antigen-specific IgG1 are elevated relative to controls in response to challenge with an allergic antigen
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• less CD4+ and CD8+ T cells are recruited to the lung after allergy challenge than controls
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• less peribronchial lymph node T cells are in an activated state after allergy challenge compared to controls
• less activated CD4+ T cells are found in the lung after allergy challenge than in controls
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• T cells from allergic mice proliferate less vigorously in response to allergic antigen than controls
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• peribronchial lymph nodes contain about twice as more B cells, CD4+ T cells, and CD8+ T cells than in controls
• peribronchial lymph nodes also contain more myeloid and plasmacytoid dendritic cells
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• dendritic cells have impaired migration to the lung of both nave and allergy challenged mice compared to respective controls
• myeloid dendritic cells in the lung fail to become activated in response to intranasal allergy challenge
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• plasmacytoid dendritic cells have impaired migration to the lung of both nave and allergy challenged mice compared to respective controls
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• mice fail to increase airway resistance in response to intranasal challenge with an antigen mice were previously sensitized too
• the number of mucus-secreting cells in the lung is half that of wild-type controls after intranasal antigen challenge
• 10-fold less antigen-specific IgE is detected in the sera of mice after antigen challenge
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• peribronchial lymph node T cells isolated from allergic mice produce much less IL-13 than controls upon reencounter with allergic antigen
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• peribronchial lymph node T cells isolated from allergic mice produce much less IL-4 than controls upon reencounter with allergic antigen
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• peribronchial lymph node T cells isolated from allergic mice produce much less IL-5 than controls upon reencounter with allergic antigen
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respiratory system
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• mice fail to increase airway resistance in response to intranasal antigen challenge
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hematopoietic system
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• eosinophils fail to migrate to the blood, lung or bronchoalveolar fluid after intranasal challenge with an antigen mice were previously sensitized to
• eosinophil numbers in the peripheral blood, airway lumen, and lung tissue remained at baseline levels for the entire observational period of 2 wk after the final antigen challenge
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• sera levels of antigen-specific IgG1 are elevated relative to controls in response to challenge with an allergic antigen
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• less CD4+ and CD8+ T cells are recruited to the lung after allergy challenge than controls
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• less peribronchial lymph node T cells are in an activated state after allergy challenge compared to controls
• less activated CD4+ T cells are found in the lung after allergy challenge than in controls
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• T cells from allergic mice proliferate less vigorously in response to allergic antigen than controls
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cellular
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• T cells from allergic mice proliferate less vigorously in response to allergic antigen than controls
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